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Obstet Gynecol
. 2023 May 4.
doi: 10.1097/AOG.0000000000005172. Online ahead of print. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Titer Levels in Pregnant Individuals After Infection, Vaccination, or Both
Christina L Marshall 1 , Elianna Kaplowitz, Erona Ibroci, Kyle Chung, Frederieke A J Gigase, Molly Lieber, Mara Graziani, Sophie Ohrn, Jezelle Lynch, Juliana Castro, Rushna Tubassum, Farida Mutawakil, Rebecca Jessel, Nina Molenaar, Anna-Sophie Rommel, Rhoda S Sperling, Elizabeth A Howell, Hannah Feldman, Florian Krammer, Daniel Stadlbauer, Lotje D de Witte, Veerle Bergink, Joanne Stone, Teresa Janevic, Siobhan M Dolan, Whitney Lieb
Affiliations
We examined differences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses in pregnant individuals with natural, vaccine-induced, or combined immunity. Participants had live or nonlive births between 2020 and 2022, were seropositive (SARS-CoV-2 spike protein, anti-S), and had available mRNA vaccination and infection information (n=260). We compared titer levels among three immunity profiles: 1) natural immunity (n=191), 2) vaccine-induced immunity (n=37), and 3) combined immunity (ie, natural and vaccine-induced immunity; n=32). We applied linear regression to compare anti-S titers between the groups, controlling for age, race and ethnicity, and time between vaccination or infection (whichever came last) and sample collection. Anti-S titers were 57.3% and 94.4% lower among those with vaccine-induced and natural immunity, respectively, compared with those with combined immunity (P<.001, P=.005).
. 2023 May 4.
doi: 10.1097/AOG.0000000000005172. Online ahead of print. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Titer Levels in Pregnant Individuals After Infection, Vaccination, or Both
Christina L Marshall 1 , Elianna Kaplowitz, Erona Ibroci, Kyle Chung, Frederieke A J Gigase, Molly Lieber, Mara Graziani, Sophie Ohrn, Jezelle Lynch, Juliana Castro, Rushna Tubassum, Farida Mutawakil, Rebecca Jessel, Nina Molenaar, Anna-Sophie Rommel, Rhoda S Sperling, Elizabeth A Howell, Hannah Feldman, Florian Krammer, Daniel Stadlbauer, Lotje D de Witte, Veerle Bergink, Joanne Stone, Teresa Janevic, Siobhan M Dolan, Whitney Lieb
Affiliations
- PMID: 37141599
- DOI: 10.1097/AOG.0000000000005172
We examined differences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses in pregnant individuals with natural, vaccine-induced, or combined immunity. Participants had live or nonlive births between 2020 and 2022, were seropositive (SARS-CoV-2 spike protein, anti-S), and had available mRNA vaccination and infection information (n=260). We compared titer levels among three immunity profiles: 1) natural immunity (n=191), 2) vaccine-induced immunity (n=37), and 3) combined immunity (ie, natural and vaccine-induced immunity; n=32). We applied linear regression to compare anti-S titers between the groups, controlling for age, race and ethnicity, and time between vaccination or infection (whichever came last) and sample collection. Anti-S titers were 57.3% and 94.4% lower among those with vaccine-induced and natural immunity, respectively, compared with those with combined immunity (P<.001, P=.005).