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Published 03 February 2023
DOI https://doi.org/10.1038/s41392-023-01340-8
Seong Dong Jeong, Hoyoung Lee, Ju Young Chang, Seong Yong Lee, Ji Eun Choi, Eunmi Yang, Hye Won Jeong, Jae-Phil Choi, Mi Seon Han & Eui-Cheol Shin
Dear Editor,
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is more likely to progress to severe disease in the elderly, and the rates of hospitalization for coronavirus disease 2019 (COVID-19) increase with age.1,2 Herein, we comprehensively compared adaptive and innate immune responses between children and adults infected with SARS-CoV-2.
A total of 57 children and 57 adult patients with confirmed SARS-CoV-2 infection were enrolled in this study. Disease severity was determined according to the NIH severity of illness categories: asymptomatic, mild, moderate, severe, and critical.3 In the current study, we grouped patients into three categories: asymptomatic, non-severe (mild and moderate), and severe (severe and critical). Thus, this study included 14 asymptomatic children, 43 non-severe children, 30 non-severe adults, and 27 severe adults, and we compared various immunological parameters among these four groups, particularly between non-severe children and adult groups. Clinical information is presented in Supplementary Table 1. ...
DOI https://doi.org/10.1038/s41392-023-01340-8
Seong Dong Jeong, Hoyoung Lee, Ju Young Chang, Seong Yong Lee, Ji Eun Choi, Eunmi Yang, Hye Won Jeong, Jae-Phil Choi, Mi Seon Han & Eui-Cheol Shin
Dear Editor,
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is more likely to progress to severe disease in the elderly, and the rates of hospitalization for coronavirus disease 2019 (COVID-19) increase with age.1,2 Herein, we comprehensively compared adaptive and innate immune responses between children and adults infected with SARS-CoV-2.
A total of 57 children and 57 adult patients with confirmed SARS-CoV-2 infection were enrolled in this study. Disease severity was determined according to the NIH severity of illness categories: asymptomatic, mild, moderate, severe, and critical.3 In the current study, we grouped patients into three categories: asymptomatic, non-severe (mild and moderate), and severe (severe and critical). Thus, this study included 14 asymptomatic children, 43 non-severe children, 30 non-severe adults, and 27 severe adults, and we compared various immunological parameters among these four groups, particularly between non-severe children and adult groups. Clinical information is presented in Supplementary Table 1. ...
