Cell Immunol . Immune system changes in those with hypertension when infected with SARS-CoV-2

[tetano]

Cell Immunol


. 2022 Jun 9;378:104562.
doi: 10.1016/j.cellimm.2022.104562. Online ahead of print.
Immune system changes in those with hypertension when infected with SARS-CoV-2


Sheng Su 2 ¹ , Ruirong Chen ² , Shaofen Zhang ³ , Haihua Shu ⁴ , Jianfang Luo ⁵



Affiliations

• PMID: 35901625
• DOI: 10.1016/j.cellimm.2022.104562

Abstract

The coronavirus disease 2019 (COVID-19) outbreak has become an evolving global health crisis. With an increasing incidence of primary hypertension, there is greater awareness of the relationship between primary hypertension and the immune system [including CD4+, CD8+ T cells, interleukin-17 (IL-17)/T regulatory cells (Treg) balance, macrophages, natural killer (NK) cells, neutrophils, B cells, and cytokines]. Hypertension is associated with an increased risk of various infections, post-infection complications, and increased mortality from severe infections. Despite ongoing reports on the epidemiological and clinical features of COVID-19, no articles have systematically addressed the role of primary hypertension in COVID-19 or how COVID-19 affects hypertension or specific treatment in these high-risk groups. Here, we synthesize recent advances in understanding the relationship between primary hypertension and COVID-19 and its underlying mechanisms and provide specific treatment guidelines for these high-risk groups.

Keywords: COVID-19; Hypertension; Immune system; SARS-CoV-2; Treatment.