J Microbiol . T cell responses to SARS-CoV-2 in humans and animals

[tetano]

J Microbiol


. 2022 Feb 14.
doi: 10.1007/s12275-022-1624-z. Online ahead of print.
T cell responses to SARS-CoV-2 in humans and animals


Sameer-Ul-Salam Mattoo ¹ , Jinjong Myoung ²



Affiliations

• PMID: 35157219
• DOI: 10.1007/s12275-022-1624-z

Abstract

SARS-CoV-2, the causative agent of COVID-19, first emerged in 2019. Antibody responses against SARS-CoV-2 have been given a lot of attention. However, the armamentarium of humoral and T cells may have differing roles in different viral infections. Though the exact role of T cells in COVID-19 remains to be elucidated, prior experience with human coronavirus has revealed an essential role of T cells in the outcomes of viral infections. Moreover, an increasing body of evidence suggests that T cells might be effective against SARS-CoV-2. This review summarizes the role of T cells in mouse CoV, human pathogenic respiratory CoV in general and SARS-CoV-2 in specific.

Keywords: SARS-CoV-2; T cell; coronavirus; immune response.