Open Forum Infect Dis . Twelve-Month Follow-up of Early COVID-19 Cases in the United States: Cellular and Humoral Immune Longevity

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Open Forum Infect Dis


. 2022 Jan 5;9(3):ofab664.
doi: 10.1093/ofid/ofab664. eCollection 2022 Mar.
Twelve-Month Follow-up of Early COVID-19 Cases in the United States: Cellular and Humoral Immune Longevity


Melisa M Shah ^{1 2} , Mohammad Ata Ur Rasheed ¹ , Jennifer L Harcourt ¹ , Glen R Abedi ¹ , Megan M Stumpf ¹ , Hannah L Kirking ¹ , Azaibi Tamin ¹ , Lisa Mills ¹ , Madeleine Armstrong ³ , Phillip P Salvatore ^{1 2} , Krishna Surasi ^{2 4} , Sarah E Scott ⁵ , Marie E Killerby ¹ , Melissa Briggs-Hagen ¹ , Sharon Saydah ¹ , Jacqueline E Tate ¹ , Alicia M Fry ¹ , Aron J Hall ¹ , Natalie J Thornburg ¹ , Claire M Midgley ¹ , COVID-19 Follow-Up Investigation Team



Collaborators, Affiliations

• PMID: 35141347
• PMCID: PMC8755399
• DOI: 10.1093/ofid/ofab664

Abstract

We quantify antibody and memory B-cell responses to severe acute respiratory syndrome coronavirus 2 at 6 and 12 months postinfection among 7 unvaccinated US coronavirus disease 2019 cases. All had detectable S-specific memory B cells and immunoglobulin G at both time points, with geometric mean titers of 117.2 BAU/mL and 84.0 BAU/mL at 6 and 12 months, respectively.

Keywords: COVID-19; SARS-CoV-2 infection; immunity; memory B cells.