Dokl Biochem Biophys . Antibodies to the N-Terminal Domain of Angiotensin-Converting Enzyme (ACE2) That Block Its Interaction with SARS-CoV-2 S Protein

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Dokl Biochem Biophys


. 2021 Dec 4.
doi: 10.1134/S160767292201001X. Online ahead of print.
Antibodies to the N-Terminal Domain of Angiotensin-Converting Enzyme (ACE2) That Block Its Interaction with SARS-CoV-2 S Protein


V G Krut ¹ , I V Astrakhantseva ¹ , S A Chuvpilo ¹ , G A Efimov ² , S G Ambaryan ¹ , M S Drutskaya ^{1 3} , S A Nedospasov ^{4 5}



Affiliations

• PMID: 34874527
• DOI: 10.1134/S160767292201001X

Abstract

SARS-CoV-2 is a new coronavirus that is the cause of COVID-19 pandemic. To enter the cell, the virus interacts via its surface S protein with angiotensin-converting enzyme 2 (ACE2), the main entry receptor on the cell membrane. Most of protective antibodies, including those induced by vaccinations, target the S protein, preventing its interaction with the ACE2 receptor. We have evaluated an alternative strategy for blocking the S-ACE2 interaction using new antipeptide antibodies to the N-terminus of the ACE2 molecule. These antibodies allow detection of human ACE2 in vitro and ex vivo.

Keywords: COVID-19; peplomers; peptides; receptor.