Eur J Clin Microbiol Infect Dis

. 2021 Oct 9.
doi: 10.1007/s10096-021-04360-w. Online ahead of print.
Clinical and immunological characteristics in COVID-19 convalescent patients

Zhiying Su # 1 , Wenjia Hu # 1 , Qianyun Liu # 2 , Yongxi Zhang 1 , Tielong Chen 1 , Yingying Zhou 1 , Zhen Zhang 2 , Yu Chen # 2 , Rongrong Yang # 1 , Yong Xiong # 3 , Xinghuan Wang # 4



The humoral and cellular immunity of convalescent COVID-19 patients is involved in pathogenesis and vaccine immunity. In this study, through CoV-psV neutralization assay and IFN-γ ELISpot testing in 30 cases of COVID-19 patients after 9 months post-SARS-CoV-2 infection, it found that the ratio of memory/naive CD4+ T lymphocytes cells and levels of anti-SARS-CoV-2-IgM and RBD-IgM were slightly but significantly higher in COVID-19 severe convalescent patients than that in non-severe patients. The specific cellular and humoral immunity against SARS-CoV-2 were detectable, regardless of the severity of the disease in the acute phase. This information may help understanding the immune status after SARS-CoV-2 infection.

Keywords: Humoral immunity; Neutralizing antibodies; SARS-CoV-2; Virus-specific T cells.