Cells . The Role of Th17 Response in COVID-19

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Cells


. 2021 Jun 19;10(6):1550.
doi: 10.3390/cells10061550.
The Role of Th17 Response in COVID-19


Diana Martonik ¹ , Anna Parfieniuk-Kowerda ¹ , Magdalena Rogalska ¹ , Robert Flisiak ¹



Affiliations

• PMID: 34205262
• DOI: 10.3390/cells10061550

Abstract

COVID-19 is an acute infectious disease of the respiratory system caused by infection with the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2). Transmission of SARS-CoV-2 infections occurs through droplets and contaminated objects. A rapid and well-coordinated immune system response is the first line of defense in a viral infection. However, a disturbed and over-activated immune response may be counterproductive, causing damage to the body. Severely ill patients hospitalised with COVID-19 exhibit increased levels of many cytokines, including Interleukin (IL)-1β, IL-2, IL-6, IL-7, IL-8, IL-10, IL-17, granulocyte colony stimulating factor (G-CSF), monocyte chemoattractant protein 1 (MCP-1) and tumor necrosis factor (TNF). Increasing evidence suggests that Th17 cells play an important role in the pathogenesis of COVID-19, not only by activating cytokine cascade but also by inducing Th2 responses, inhibiting Th1 differentiation and suppressing Treg cells. This review focuses on a Th17 pathway in the course of the immune response in COVID-19, and explores plausible targets for therapeutic intervention.

Keywords: COVID-19 pneumonia; SARS-CoV-2; Th17 response; cytokines.