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Emerg Infect Dis
. 2021 Feb;27(2):663-666.
doi: 10.3201/eid2702.204226.
Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam
Huynh Kim Mai, Nguyen Bao Trieu, Trinh Hoang Long, Hoang Tien Thanh, Nguyen Dinh Luong, Le Xuan Huy, Lam Anh Nguyet, Dinh Nguyen Huy Man, Danielle E Anderson, Tran Tan Thanh, Nguyen Van Vinh Chau, Guy Thwaites, Lin-Fa Wang, Le Van Tan, Do Thai ****
- PMID: 33496647
- DOI: 10.3201/eid2702.204226
Abstract
Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18-30 after diagnosis, all remained seropositive but spike protein-targeting antibody titers declined. These data may be useful for vaccine development.
Keywords: COVID-19; SARS-CoV-2; SARS-CoV-2 spike protein; asymptomatic coronavirus disease; immune response; neutralizing antibodies; respiratory infections; viruses.