Transbound Emerg Dis . Piglets inoculated by different routes are not susceptible to SARS-CoV-2, but those inoculated parenterally were immunized against the virus

[tetano]

Transbound Emerg Dis


. 2020 Oct 2.
doi: 10.1111/tbed.13861. Online ahead of print.
Piglets inoculated by different routes are not susceptible to SARS-CoV-2, but those inoculated parenterally were immunized against the virus


J?lia Vergara-Alert ^{1 2} , Jordi Rodon ¹ , Jorge Carrillo ³ , Nigeer Te ¹ , Nuria Izquierdo-Useros ^{3 4} , Mar?a Luisa Rodr?guez de, la Concepci?n ³ , Carlos ?vila-Nieto ³ , V?ctor Guallar ^{5 6} , Alfonso Valencia ^{5 6} , Guillermo Cantero ¹ , Juli? Blanco ^{3 4 7} , Bonaventura Clotet ^{3 4 7} , Albert Bensaid ^{1 2} , Joaquim Segal?s ^{2 8 9}



Affiliations

• PMID: 33007154
• DOI: 10.1111/tbed.13861

Abstract

Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. Although piglets were not susceptible to SARS-CoV-2 and lacked lesions or viral RNA in tissues/swabs, seroconversion was observed in pigs inoculated parenterally (intramuscularly or intravenously).

Keywords: SARS-CoV-2; immunogenicity model; inoculation routes; lack of susceptibility; pig.