BMC Infect Dis . COVID-19 confirmed patients with negative antibodies results

[tetano]

BMC Infect Dis


. 2020 Sep 22;20(1):698.
doi: 10.1186/s12879-020-05419-3.
COVID-19 confirmed patients with negative antibodies results


Jian Wang ^{1 2} , Chong Chen ³ , Qilin Li ^{1 2} , Pengcheng Cai ¹ , Zheng Wang ^{4 5} , Lin Wang ^{6 7}



Affiliations

• PMID: 32962655
• DOI: 10.1186/s12879-020-05419-3

Free article

Abstract

Background: A new coronavirus disease 2019 (COVID-19) has escalated to a pandemic since its first outbreak in Wuhan, China. A small proportion of patients may have difficulty in generating IgM or IgG antibodies against SARS-CoV-2, and little attention has been paid to them.
Case presentations: We present two cases of confirmed COVID-19 patients and characterize their initial symptoms, chest CT results, medication, and laboratory test results in detail (including RT-PCR, IgM/ IgG, cytokine and blood cell counts).
Conclusion: Both of patients with confirmed COVID-19 pneumonia failed to produce either IgM or IgG even 40 to 50 days after their symptoms onset. This work provides evidence demonstrating that at least a small proportion of patients may have difficulty in rapidly gaining immunity against SARS-CoV-2.

Keywords: COVID-19; Case report; IgG; IgM; Negative antibodies results.