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J Exp Med. 2020 Jun 1;217(6). pii: e20200678. doi: 10.1084/jem.20200678.
The many faces of the anti-COVID immune response.
Vardhana SA1,2,3, Wolchok JD3,4,5.
Author information
Abstract
The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.
? 2020 Vardhana and Wolchok.
PMID:32353870DOI:10.1084/jem.20200678