Tweet
J Infect Dis. 2018 May 28. doi: 10.1093/infdis/jiy317. [Epub ahead of print]
Clinical Correlations of Transcriptional Profile in Patients Infected with Avian Influenza H7N9 Virus.
Guan W1, Wu NC2, Lee HHY3, Li Y1, Jiang W4, Shen L5, Wu DC6, Chen R1, Zhong N1, Wilson IA2,7, Peiris M1,3, Yang Z1, Mok CKP1,3.
Author information
Abstract
Background:
Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis.
Methods:
We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis.
Results:
We found that specific gene expression profiles in the blood were strongly correlated with the PaO2/FiO2 ratio and viral load in the lower respiratory tract (LRT). Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found.
Conclusions:
We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.
PMID: 29846612 DOI: 10.1093/infdis/jiy317
Clinical Correlations of Transcriptional Profile in Patients Infected with Avian Influenza H7N9 Virus.
Guan W1, Wu NC2, Lee HHY3, Li Y1, Jiang W4, Shen L5, Wu DC6, Chen R1, Zhong N1, Wilson IA2,7, Peiris M1,3, Yang Z1, Mok CKP1,3.
Author information
Abstract
Background:
Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis.
Methods:
We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis.
Results:
We found that specific gene expression profiles in the blood were strongly correlated with the PaO2/FiO2 ratio and viral load in the lower respiratory tract (LRT). Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found.
Conclusions:
We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.
PMID: 29846612 DOI: 10.1093/infdis/jiy317