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Sci Rep. 2015 Jan 15;5:7630. doi: 10.1038/srep07630.
Poultry farms as a source of avian influenza A (H7N9) virus reassortment and human infection.
Wu D1, Zou S2, Bai T2, Li J1, Zhao X2, Yang L2, Liu H1, Li X2, Yang X1, Xin L2, Xu S1, Zou X2, Li X2, Wang A1, Guo J2, Sun B3, Huang W2, Zhang Y2, Li X1, Gao R2, Shen B1, Chen T2, Dong J2, Wei H2, Wang S2, Li Q4, Li D2, Wu G2, Feng Z4, Gao GF5, Wang Y4, Wang D2, Fan M1, Shu Y2.
Author information
Abstract
Live poultry markets are a source of human infection with avian influenza A (H7N9) virus. On February 21, 2014, a poultry farmer infected with H7N9 virus was identified in Jilin, China, and H7N9 and H9N2 viruses were isolated from the patient's farm. Reassortment between these subtype viruses generated five genotypes, one of which caused the human infection. The date of H7N9 virus introduction to the farm is estimated to be between August 21, 2013 (95% confidence interval [CI] June 6, 2013-October 6, 2013) and September 25, 2013 (95% CI May 28, 2013-January 4, 2014), suggesting that the most likely source of virus introduction was the first batch of poultry purchased in August 2013. The reassortment event that led to the human virus may have occurred between January 2, 2014 (95% CI November 8, 2013-February 12, 2014) and February 12, 2014 (95% CI January 19, 2014-February 18, 2014). Our findings demonstrate that poultry farms could be a source of reassortment between H7N9 virus and H9N2 virus as well as human infection, which emphasizes the importance to public health of active avian influenza surveillance at poultry farms.
PMID: 25591105 [PubMed - in process]
Poultry farms as a source of avian influenza A (H7N9) virus reassortment and human infection.
Wu D1, Zou S2, Bai T2, Li J1, Zhao X2, Yang L2, Liu H1, Li X2, Yang X1, Xin L2, Xu S1, Zou X2, Li X2, Wang A1, Guo J2, Sun B3, Huang W2, Zhang Y2, Li X1, Gao R2, Shen B1, Chen T2, Dong J2, Wei H2, Wang S2, Li Q4, Li D2, Wu G2, Feng Z4, Gao GF5, Wang Y4, Wang D2, Fan M1, Shu Y2.
Author information
Abstract
Live poultry markets are a source of human infection with avian influenza A (H7N9) virus. On February 21, 2014, a poultry farmer infected with H7N9 virus was identified in Jilin, China, and H7N9 and H9N2 viruses were isolated from the patient's farm. Reassortment between these subtype viruses generated five genotypes, one of which caused the human infection. The date of H7N9 virus introduction to the farm is estimated to be between August 21, 2013 (95% confidence interval [CI] June 6, 2013-October 6, 2013) and September 25, 2013 (95% CI May 28, 2013-January 4, 2014), suggesting that the most likely source of virus introduction was the first batch of poultry purchased in August 2013. The reassortment event that led to the human virus may have occurred between January 2, 2014 (95% CI November 8, 2013-February 12, 2014) and February 12, 2014 (95% CI January 19, 2014-February 18, 2014). Our findings demonstrate that poultry farms could be a source of reassortment between H7N9 virus and H9N2 virus as well as human infection, which emphasizes the importance to public health of active avian influenza surveillance at poultry farms.
PMID: 25591105 [PubMed - in process]
