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Virol J. 2014 Oct 23;11(1):184. [Epub ahead of print]
Serologic screenings for H7N9 from three sources among high-risk groups in the early stage of H7N9 circulation in Guangdong Province, China.
Wu J, Zou L, Ni H, Pei L, Zeng X, Liang L, Zhong H, He J, Song Y, Kang M, Zhang X, Lin J, Ke C.
Abstract
BACKGROUND:
The aim of this study was to assess the prevalence of the novel avian influenza A virus (H7N9) in three high risk groups. The groups were divided into those exposed through infected individuals, those exposed through poultry and those individuals exposed through the external environment, in the early stage of the epidemic in Guangdong Province, which is located in the southern region of China.
METHODS:
Serologic studies were conducted among samples collected from individuals who had close contact with the first H7N9 infected patient reported in Guangdong Province, those who were most likely exposed to the first group of H7N9 infected poultry, and those who might have been exposed to H7N9 in the environmental settings, using hemagglutinin inhibition (HI) and microneutralization(MN) with 3 viruses as antigens.
RESULTS:
The alignment results indicated that the similarity of the HA gene sequence among viruses from exposure to infected poultry, infected humans and contaminated environments were highly conserved. Seven samples of individuals exposed to contaminated environments were positive using HI and one sample among them was positive using MN using poultry H7N9 virus as the antigen. One sample was positive against human H7N9 virus and 3 samples were positive against environmental H7N9 among those that were in contact with infected patients with HI. None of these were positive with MN. All HI titers of the 240 samples from those individuals in contact with infected poultry were less than 40 with 3 viruses as antigens.
CONCLUSIONS:
The results suggest that when the H7N9 virus was in the early stages of circulation in Guangdong Province, the antigenic sites of the HA proteins of the H7N9 strains from different hosts were highly conserved. The risk of new infection is low in individuals who have contact with infected patients, poultry or a contaminated environment in the early stages of the circulation of the H7N9 virus.
PMID:
25342002
[PubMed - as supplied by publisher]
Free full text
Serologic screenings for H7N9 from three sources among high-risk groups in the early stage of H7N9 circulation in Guangdong Province, China.
Wu J, Zou L, Ni H, Pei L, Zeng X, Liang L, Zhong H, He J, Song Y, Kang M, Zhang X, Lin J, Ke C.
Abstract
BACKGROUND:
The aim of this study was to assess the prevalence of the novel avian influenza A virus (H7N9) in three high risk groups. The groups were divided into those exposed through infected individuals, those exposed through poultry and those individuals exposed through the external environment, in the early stage of the epidemic in Guangdong Province, which is located in the southern region of China.
METHODS:
Serologic studies were conducted among samples collected from individuals who had close contact with the first H7N9 infected patient reported in Guangdong Province, those who were most likely exposed to the first group of H7N9 infected poultry, and those who might have been exposed to H7N9 in the environmental settings, using hemagglutinin inhibition (HI) and microneutralization(MN) with 3 viruses as antigens.
RESULTS:
The alignment results indicated that the similarity of the HA gene sequence among viruses from exposure to infected poultry, infected humans and contaminated environments were highly conserved. Seven samples of individuals exposed to contaminated environments were positive using HI and one sample among them was positive using MN using poultry H7N9 virus as the antigen. One sample was positive against human H7N9 virus and 3 samples were positive against environmental H7N9 among those that were in contact with infected patients with HI. None of these were positive with MN. All HI titers of the 240 samples from those individuals in contact with infected poultry were less than 40 with 3 viruses as antigens.
CONCLUSIONS:
The results suggest that when the H7N9 virus was in the early stages of circulation in Guangdong Province, the antigenic sites of the HA proteins of the H7N9 strains from different hosts were highly conserved. The risk of new infection is low in individuals who have contact with infected patients, poultry or a contaminated environment in the early stages of the circulation of the H7N9 virus.
PMID:
25342002
[PubMed - as supplied by publisher]
Free full text
