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J Infect. 2013 Aug 16. pii: S0163-4453(13)00239-9. doi: 10.1016/j.jinf.2013.08.007. [Epub ahead of print]
A comparison of the epidemiological, clinical and viral characteristics between survivors and deaths infected with human avian influenza a (H7N9) virus in Zhejiang province, China.
Liu S, Sun J, Cai J, Miao Z, Lu M, Qin S, Wang X, Lv H, Yu Z, Amer S, Chai C.
Source
Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, 630 Xincheng Road, Binjiang District, Hangzhou, Zhejiang 310051, China.
Abstract
BACKGROUND:
The widespread of avian influenza H7N9 in human, with noticeable high mortality in China has been recognized as a great public health concern.
METHODS:
A retrospective study was performed involving 30 survivors and 10 deaths. Epidemiological, clinical and viral features were compared to determine the risk factors associated with fatal outcome of H7N9 infections.
RESULTS:
The present study proved that age (p=0.021), smoking (p=0.04), underlying medical background (p=0.05) and chronic drug use (p=0.042) had a strong relationship with death due to H7N9 infection. The biochemical markers of the sera were higher in the deaths compared to those survivors. Acute respiratory distress syndrome (100%), respiratory failure (100%), co-infection with bacteria (60%); shock (50%) and congestive heart failure (50%) were most the common complications in the deaths. The median time from onset of symptoms to antiviral therapy was 4.6 and 7.4 days among the survivors and deaths, respectively (p=0.04). Viral HA, NA and MP nucleotide sequences of isolates from both study groups showed high homology.
CONCLUSIONS:
Age along with smoking rate, chronic lung disease, immunosuppressive disorders, chronic drug use and delayed Oseltamivir treatment are the high risk factors which might contribute to the observed fatal outcomes in human H7N9 infection.
? 2013 Published by Elsevier Ltd on behalf of The British Infection Association.
KEYWORDS:
Avian influenza A (H7N9) virus, Clinical symptoms, Epidemiology, Fatal outcome
PMID:
23958687
[PubMed - as supplied by publisher]
A comparison of the epidemiological, clinical and viral characteristics between survivors and deaths infected with human avian influenza a (H7N9) virus in Zhejiang province, China.
Liu S, Sun J, Cai J, Miao Z, Lu M, Qin S, Wang X, Lv H, Yu Z, Amer S, Chai C.
Source
Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, 630 Xincheng Road, Binjiang District, Hangzhou, Zhejiang 310051, China.
Abstract
BACKGROUND:
The widespread of avian influenza H7N9 in human, with noticeable high mortality in China has been recognized as a great public health concern.
METHODS:
A retrospective study was performed involving 30 survivors and 10 deaths. Epidemiological, clinical and viral features were compared to determine the risk factors associated with fatal outcome of H7N9 infections.
RESULTS:
The present study proved that age (p=0.021), smoking (p=0.04), underlying medical background (p=0.05) and chronic drug use (p=0.042) had a strong relationship with death due to H7N9 infection. The biochemical markers of the sera were higher in the deaths compared to those survivors. Acute respiratory distress syndrome (100%), respiratory failure (100%), co-infection with bacteria (60%); shock (50%) and congestive heart failure (50%) were most the common complications in the deaths. The median time from onset of symptoms to antiviral therapy was 4.6 and 7.4 days among the survivors and deaths, respectively (p=0.04). Viral HA, NA and MP nucleotide sequences of isolates from both study groups showed high homology.
CONCLUSIONS:
Age along with smoking rate, chronic lung disease, immunosuppressive disorders, chronic drug use and delayed Oseltamivir treatment are the high risk factors which might contribute to the observed fatal outcomes in human H7N9 infection.
? 2013 Published by Elsevier Ltd on behalf of The British Infection Association.
KEYWORDS:
Avian influenza A (H7N9) virus, Clinical symptoms, Epidemiology, Fatal outcome
PMID:
23958687
[PubMed - as supplied by publisher]
