J Med Virol . On the SARS-CoV-2 BA.2.75 variant: a genetic and structural point of view

[tetano]

J Med Virol


. 2022 Sep 4.
doi: 10.1002/jmv.28119. Online ahead of print.
On the SARS-CoV-2 BA.2.75 variant: a genetic and structural point of view


Fabio Scarpa ¹ , Daria Sanna ¹ , Ilenia Azzena ^{1 2} , Marta Giovanetti ^{3 4} , Domenico Benvenuto ⁵ , Silvia Angeletti ⁶ , Giancarlo Ceccarelli ⁷ , Stefano Pascarella ⁸ , Marco Casu ² , Pier Luigi Fiori ¹ , Massimo Ciccozzi ⁵



Affiliations

• PMID: 36059082
• DOI: 10.1002/jmv.28119

Abstract

Due to the continuing evolution of SARS-CoV-2, the formation of new variants is not a novelty or a sporadic case, but it is a certainty that periodically recurs [1]. One of the most recent variant is represented by the subvariant BA.2.75, also known as Centaurus. In comparison to the BA.2 variant, BA.2.75 carries nine additional mutations in the sequence of spike protein gene: K147E, W152R, F157L, I210V, G257S G339H, G446S, N460K, and R493Q. The site G446S has been indicated as site of potential escape from antibodies evoked by current vaccines that are capable of neutralizing Omicron 5 [2] and it has been hypothesized that the BA.2.75 spike significantly reduces sensitivity towards therapeutic monoclonal antibodies than BA.5 (and thus than BA.2 and BA.4) [3]. Here below you can find a genetic and structural point of view: This article is protected by copyright. All rights reserved.

Keywords: Coronavirus; Epidemiology; Pandemics; SARS coronavirus; Virus classification.