Sci Rep . Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal

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Sci Rep


. 2021 Dec 8;11(1):23644.
doi: 10.1038/s41598-021-02874-z.
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal


Ambroise D Ahouidi ^{# 1} , Mary A Rodgers ^{# 2} , Abdou Padane ³ , Nafissatou Leye ³ , Ana Olivo ⁴ , Moustapha Mbow ³ , Aminata Mboup ³ , Papa Alassane Diaw ³ , Aminata Dia ³ , Barbara Harris ⁴ , Yacine Amet Dia Padane ³ , Gora Lo ³ , Todd V Meyer ⁴ , Cyrille K Diedhiou ³ , Diabou Diagne ³ , Ndeye Coumba Toure Kane ³ , Gavin Cloherty ⁴ , Souleymane Mboup ³



Affiliations

• PMID: 34880295
• DOI: 10.1038/s41598-021-02874-z

Abstract

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages.