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Infect Genet Evol . Genetic polymorphisms as multi-biomarkers in severe acute respiratory syndrome (SARS) by coronavirus infection: A systematic review of candidate gene association studies

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  • Infect Genet Evol . Genetic polymorphisms as multi-biomarkers in severe acute respiratory syndrome (SARS) by coronavirus infection: A systematic review of candidate gene association studies


    Infect Genet Evol


    . 2021 Apr 29;104846.
    doi: 10.1016/j.meegid.2021.104846. Online ahead of print.
    Genetic polymorphisms as multi-biomarkers in severe acute respiratory syndrome (SARS) by coronavirus infection: A systematic review of candidate gene association studies


    Ana Caroline Melo Dos Santos 1 , Bárbara Rayssa Correia Dos Santos 1 , Bruna Brandão Dos Santos 1 , Edilson Leite de Moura 1 , Jean Moisés Ferreira 1 , Luana Karen Correia Dos Santos 1 , Susana Paiva Oliveira 1 , Renise Bastos Farias Dias 1 , Aline Cristine Pereira E Silva 1 , Karol Fireman de Farias 1 , Elaine Virgínia Martins de Souza Figueiredo 2



    Affiliations

    Abstract

    The Severe acute respiratory syndrome may be caused by coronavirus disease which has resulted in a global pandemic. Polymorphisms in the population play a role in susceptibility to severity. We aimed to perform a systematic review related to the effect of single nucleotide polymorphisms in the development of severe acute respiratory syndrome (SARS). Twenty-eight eligible articles published were identified in PubMed, ScienceDirect, Web of Science, PMC Central and Portal BVS and additional records, with 20 studies performed in China. Information on study characteristics, genetic polymorphisms, and comorbidities was extracted. Study quality was assessed by the STrengthening the REporting of Genetic Association (STREGA) guideline. Few studies investigated the presence of polymorphisms in HLA, ACE1, OAS-1, MxA, PKR, MBL, E-CR1, Fc?RIIA, MBL2, L-SIGN (CLEC4M), IFNG, CD14, ICAM3, RANTES, IL-12 RB1, TNFA, CXCL10/IP-10, CD209 (DC-SIGN), AHSG, CYP4F3 and CCL2 with the susceptibility or protection to SARS-Cov. This review provides comprehensive evidence of the association between genetic polymorphisms and susceptibility or protection to severity SARS-CoV. The literature about coronavirus infection, susceptibility to severe acute respiratory syndrome (SARS) and genetic variations is scarce. Further studies are necessary to provide more concrete evidence, mainly related to Covid-19.

    Keywords: Coronavirus; Genetic polymorphism; Severe acute respiratory syndrome; Susceptibility.

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