HLA . Association of HLA-B22 serotype with SARS-CoV-2 susceptibility in Hong Kong Chinese patients

[tetano]

HLA


. 2020 Nov 12.
doi: 10.1111/tan.14135. Online ahead of print.
Association of HLA-B22 serotype with SARS-CoV-2 susceptibility in Hong Kong Chinese patients


Yuk-Lin Yung ¹ , Chi-Keung Cheng ¹ , Hoi-Yun Chan ¹ , Jenny T Xia ¹ , Kin-Mang Lau ¹ , Raymond S M Wong ^{2 3} , Alan K L Wu ⁴ , Raymond W Chu ⁴ , Alice C C Wong ⁵ , Eudora Y D Chow ⁵ , Sze-Fai Yip ⁶ , Jennifer N S Leung ⁷ , Cheuk-Kwong Lee ⁷ , Margaret H L Ng ^{1 8}



Affiliations

• PMID: 33179437
• DOI: 10.1111/tan.14135

Abstract

The coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by SARS-CoV-2. Since its first report in December 2019, COVID-19 has evolved into a global pandemic causing massive healthcare and socio-economic challenges. HLA system is critical in mediating anti-viral immunity and recent studies have suggested preferential involvement of HLA-B in COVID-19 susceptibility. Here, by investigating the HLA-B genotypes in 190 unrelated Chinese patients with confirmed COVID-19, we identified a significant positive association between the B22 serotype and SARS-CoV-2 infection (P=0.002, Bonferroni-corrected P=0.032). Notably, the B22 serotype has been consistently linked to susceptibility to other viral infections. These data not only shed new insights into SARS-CoV-2 pathogenesis and vaccine development but also guide better infection prevention/control. This article is protected by copyright. All rights reserved.

Keywords: COVID-19; Chinese; HLA; SARS-CoV-2; coronavirus.