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J Virol. High genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses.
High genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses. (J Virol., abstract, edited)
[Source: US National Library of Medicine, (LINK). Abstract, edited.]
J. Virol. doi:10.1128/JVI.01140-10
Copyright (c) 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.
High genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses.
C?ssio Pontes Octaviani, Makoto Ozawa, Shinya Yamada, Hideo Goto, and Yoshihiro Kawaoka* - Division of Virology, Department of Microbiology and Immunology and Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639; ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012; Influenza Research Institute, Dept. of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711; Department of Microbiology and Infectious Diseases, Kobe University, Hyogo 650-0017, Japan; and Creative Research Initiative, Sousei, Hokkaido University, Sapporo 060-0818, Japan - * To whom correspondence should be addressed. Email: kawaoka@ims.u-tokyo.ac.jp.
Abstract
Reassortment is an important mechanism for the evolution of influenza viruses. Here, we co-infected cultured cells with the pandemic swine-origin influenza virus (S-OIV) and a contemporary H5N1 virus and found that these two viruses have high genetic compatibility. Studies in human lung cell lines indicated that some reassortants had better growth kinetics than their parental viruses. We conclude that reassortment between these two viruses can occur and could create pandemic H5N1 viruses.
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[Source: US National Library of Medicine, (LINK). Abstract, edited.]
J. Virol. doi:10.1128/JVI.01140-10
Copyright (c) 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.
High genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses.
C?ssio Pontes Octaviani, Makoto Ozawa, Shinya Yamada, Hideo Goto, and Yoshihiro Kawaoka* - Division of Virology, Department of Microbiology and Immunology and Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639; ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012; Influenza Research Institute, Dept. of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711; Department of Microbiology and Infectious Diseases, Kobe University, Hyogo 650-0017, Japan; and Creative Research Initiative, Sousei, Hokkaido University, Sapporo 060-0818, Japan - * To whom correspondence should be addressed. Email: kawaoka@ims.u-tokyo.ac.jp.
Abstract
Reassortment is an important mechanism for the evolution of influenza viruses. Here, we co-infected cultured cells with the pandemic swine-origin influenza virus (S-OIV) and a contemporary H5N1 virus and found that these two viruses have high genetic compatibility. Studies in human lung cell lines indicated that some reassortants had better growth kinetics than their parental viruses. We conclude that reassortment between these two viruses can occur and could create pandemic H5N1 viruses.
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