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Case report
Influenza A (H1N1) virus-induced hepatocellular injury in a kidney transplant patient
M. Daud? 1 , J.M. Mansuy 2,3 , J. Guitard 1 , G. Basse 1 , L. Esposito 1 , J. Izopet 2,3 , L. Rostaing 1,3 , N. Kamar 1,4
1 Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France , 2 Department of Virology, CHU Purpan, Toulouse, France , 3 INSERM U563, IFR 30, CHU Purpan, Toulouse, France , 4 INSERM U858, IFR 31, CHU Rangueil, Toulouse, France
Correspondence to:
Nassim Kamar, MD, PhD, Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse, Cedex 9, France
Tel: +33 5 61 32 26 84
Fax: +33 5 61 32 28 64
E-mail: kamar.n@chu-toulouse.fr
Copyright ? 2010 John Wiley & Sons A/S
KEYWORDS
H1N1 ? kidney transplantation ? acute hepatitis ? oseltamivir
ABSTRACT
M. Daud?, J.M. Mansuy, J. Guitard, G. Basse, L. Esposito, J. Izopet, L. Rostaing, N. Kamar. Influenza A (H1N1) virus-induced hepatocellular injury in a kidney transplant patient.
Transpl Infect Dis 2010. All rights reserved.
Abstract: The swine-origin influenza A (H1N1) virus is mainly responsible for flu. No hepatitis attributable to H1N1 virus has been previously documented. Herein, we report on a kidney transplant patient who developed influenza H1N1 virus-induced hepatocellular injury. The patient's body temperature was only somewhat elevated, and pulmonary and flu symptoms were mild. H1N1 virus was detected by polymerase chain reaction assay in nasopharyngeal and bronchoalveolar swabs, as well as in the serum. The hepatocellular injury episode resolved after the patient had been placed on oseltamivir therapy. This observation suggests that acute hepatocellular injury could be linked to the influenza H1N1 virus.
Received 11 January 2010, revised 27 March 2010, accepted for publication 8 May 2010
DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1399-3062.2010.00551.x About DOI
Influenza A (H1N1) virus-induced hepatocellular injury in a kidney transplant patient
M. Daud? 1 , J.M. Mansuy 2,3 , J. Guitard 1 , G. Basse 1 , L. Esposito 1 , J. Izopet 2,3 , L. Rostaing 1,3 , N. Kamar 1,4
1 Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France , 2 Department of Virology, CHU Purpan, Toulouse, France , 3 INSERM U563, IFR 30, CHU Purpan, Toulouse, France , 4 INSERM U858, IFR 31, CHU Rangueil, Toulouse, France
Correspondence to:
Nassim Kamar, MD, PhD, Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse, Cedex 9, France
Tel: +33 5 61 32 26 84
Fax: +33 5 61 32 28 64
E-mail: kamar.n@chu-toulouse.fr
Copyright ? 2010 John Wiley & Sons A/S
KEYWORDS
H1N1 ? kidney transplantation ? acute hepatitis ? oseltamivir
ABSTRACT
M. Daud?, J.M. Mansuy, J. Guitard, G. Basse, L. Esposito, J. Izopet, L. Rostaing, N. Kamar. Influenza A (H1N1) virus-induced hepatocellular injury in a kidney transplant patient.
Transpl Infect Dis 2010. All rights reserved.
Abstract: The swine-origin influenza A (H1N1) virus is mainly responsible for flu. No hepatitis attributable to H1N1 virus has been previously documented. Herein, we report on a kidney transplant patient who developed influenza H1N1 virus-induced hepatocellular injury. The patient's body temperature was only somewhat elevated, and pulmonary and flu symptoms were mild. H1N1 virus was detected by polymerase chain reaction assay in nasopharyngeal and bronchoalveolar swabs, as well as in the serum. The hepatocellular injury episode resolved after the patient had been placed on oseltamivir therapy. This observation suggests that acute hepatocellular injury could be linked to the influenza H1N1 virus.
Received 11 January 2010, revised 27 March 2010, accepted for publication 8 May 2010
DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1399-3062.2010.00551.x About DOI
