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J Infect Dis. Predictors and Outcomes of Respiratory Failure among Hospitalized Pneumonia Patients with 2009 H1N1 Influenza in Taiwan.
J Infect. 2009 Dec 24. [Epub ahead of print]
Predictors and Outcomes of Respiratory Failure among Hospitalized Pneumonia Patients with 2009 H1N1 Influenza in Taiwan.
Chien YS, Su CP, Tsai HT, Huang AS, Lien CE, **** MN, Chuang JH, Kuo HS, Chang SC. - Field Epidemiology Training Program, Centers for Disease Control, Taiwan, R.O.C; Epidemic Intelligence Center, Centers for Disease Control, Department of Health, Taipei, Taiwan, R.O.C.
OBJECTIVES:
The worldwide outbreak of a pandemic influenza A (H1N1) virus began in April 2009. We characterized the clinical features of the hospitalized pneumonia patients with 2009 H1N1 influenza in Taiwan and elucidated the risk of those patients for developing respiratory failure.
METHODS:
Severe complicated influenza infection is a notifiable disease in Taiwan and the hospitalized pneumonia patients with 2009 H1N1 influenza were reported accordingly. We reviewed the medical records of the eligible cases by September 8, 2009; development of respiratory failure was the primary endpoint.
RESULTS:
Of the 96 patients we studied, 22 (23%) developed respiratory failure. Among those, 10 (45%) died and all of the non-respiratory failure patients survived. Age distribution, presence of dyspnea, lymphopenia, leukopenia, PaO(2) / FiO(2) ratio, PaCO(2), SOFA score, infiltration on chest x-ray at admission were different between two groups by univariate analysis. The clinical course was also different, with longer duration from onset of symptoms to use of oseltamivir, longer hospital stay, and more complications during hospitalization in patients with respiratory failure. A multivariate logistic regression showed an association between development of respiratory failure and SOFA score >= 4 at admission, initial lymphocyte count <= 800 /muL, and the duration from symptom onset to initiation of oseltamivir > 48 hours.
Copyright ? 2009. Published by Elsevier Ltd.
PMID: 20036689 [PubMed - as supplied by publisher]
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Predictors and Outcomes of Respiratory Failure among Hospitalized Pneumonia Patients with 2009 H1N1 Influenza in Taiwan.
Chien YS, Su CP, Tsai HT, Huang AS, Lien CE, **** MN, Chuang JH, Kuo HS, Chang SC. - Field Epidemiology Training Program, Centers for Disease Control, Taiwan, R.O.C; Epidemic Intelligence Center, Centers for Disease Control, Department of Health, Taipei, Taiwan, R.O.C.
OBJECTIVES:
The worldwide outbreak of a pandemic influenza A (H1N1) virus began in April 2009. We characterized the clinical features of the hospitalized pneumonia patients with 2009 H1N1 influenza in Taiwan and elucidated the risk of those patients for developing respiratory failure.
METHODS:
Severe complicated influenza infection is a notifiable disease in Taiwan and the hospitalized pneumonia patients with 2009 H1N1 influenza were reported accordingly. We reviewed the medical records of the eligible cases by September 8, 2009; development of respiratory failure was the primary endpoint.
RESULTS:
Of the 96 patients we studied, 22 (23%) developed respiratory failure. Among those, 10 (45%) died and all of the non-respiratory failure patients survived. Age distribution, presence of dyspnea, lymphopenia, leukopenia, PaO(2) / FiO(2) ratio, PaCO(2), SOFA score, infiltration on chest x-ray at admission were different between two groups by univariate analysis. The clinical course was also different, with longer duration from onset of symptoms to use of oseltamivir, longer hospital stay, and more complications during hospitalization in patients with respiratory failure. A multivariate logistic regression showed an association between development of respiratory failure and SOFA score >= 4 at admission, initial lymphocyte count <= 800 /muL, and the duration from symptom onset to initiation of oseltamivir > 48 hours.
Copyright ? 2009. Published by Elsevier Ltd.
PMID: 20036689 [PubMed - as supplied by publisher]
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