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J Clin Virol. 2015 Oct;71:44-50. doi: 10.1016/j.jcv.2015.07.308. Epub 2015 Jul 29.
A comparison of H1N1 influenza among pediatric inpatients in the pandemic and post pandemic era.
Rao S1, Torok MR2, Bagdure D3, Cunningham MA4, Williams JT5, Curtis DJ6, Wilson K4, Dominguez SR6.
Author information
Abstract
BACKGROUND:
The novel influenza A H1N1 (A[H1N1]pdm09) strain emerged in 2009, contributing to significant morbidity and mortality. It is not known whether illness associated with A(H1N1) pdm09 in the post-pandemic era exhibits a similar disease profile.
OBJECTIVE:
The objectives of this study were to compare the burden of disease of A(H1N1) pdm09 influenza from the 2009 pandemic year to the post-pandemic years (2010-2014), and to explore potential reasons for any differences.
STUDY DESIGN:
We conducted a retrospective cohort study of inpatients admitted to Children's Hospital Colorado with a positive respiratory specimen for influenza from May-December, 2009 and December, 2010-April, 2014. Univariate and multivariate analyses were conducted to compare the demographics and clinical characteristics of patients with H1N1 during the two periods.
RESULTS:
There were 388 inpatients with influenza A(H1N1) pdm09 in 2009, and 117 during the post-pandemic years. Ninety-four percent of all H1N1 during the post-pandemic era was observed during the 2013-2014 influenza season. Patients with A(H1N1) pdm09 during the post-pandemic year were less likely to have an underlying medical condition (P<0.01). Patients admitted to the ICU during the post-pandemic year had a lower median age (5 vs 8 years, P=0.01) and a lower proportion of patients were intubated, had mental status changes, and ARDS compared with the pandemic years, (P<0.01 for all), with decreased mortality (P=0.02).
CONCLUSION:
Patients with influenza A(H1N1) pdm09 during the post-pandemic years appeared to have less severe disease than patients with A(H1N1) pdm09 during the pandemic year. The reasons for this difference are likely multifactorial.
Published by Elsevier B.V.
KEYWORDS:
H1N1; Influenza; Inpatients; Pandemic; Post-pandemic period
PMID: 26370314 [PubMed - in process]
A comparison of H1N1 influenza among pediatric inpatients in the pandemic and post pandemic era.
Rao S1, Torok MR2, Bagdure D3, Cunningham MA4, Williams JT5, Curtis DJ6, Wilson K4, Dominguez SR6.
Author information
Abstract
BACKGROUND:
The novel influenza A H1N1 (A[H1N1]pdm09) strain emerged in 2009, contributing to significant morbidity and mortality. It is not known whether illness associated with A(H1N1) pdm09 in the post-pandemic era exhibits a similar disease profile.
OBJECTIVE:
The objectives of this study were to compare the burden of disease of A(H1N1) pdm09 influenza from the 2009 pandemic year to the post-pandemic years (2010-2014), and to explore potential reasons for any differences.
STUDY DESIGN:
We conducted a retrospective cohort study of inpatients admitted to Children's Hospital Colorado with a positive respiratory specimen for influenza from May-December, 2009 and December, 2010-April, 2014. Univariate and multivariate analyses were conducted to compare the demographics and clinical characteristics of patients with H1N1 during the two periods.
RESULTS:
There were 388 inpatients with influenza A(H1N1) pdm09 in 2009, and 117 during the post-pandemic years. Ninety-four percent of all H1N1 during the post-pandemic era was observed during the 2013-2014 influenza season. Patients with A(H1N1) pdm09 during the post-pandemic year were less likely to have an underlying medical condition (P<0.01). Patients admitted to the ICU during the post-pandemic year had a lower median age (5 vs 8 years, P=0.01) and a lower proportion of patients were intubated, had mental status changes, and ARDS compared with the pandemic years, (P<0.01 for all), with decreased mortality (P=0.02).
CONCLUSION:
Patients with influenza A(H1N1) pdm09 during the post-pandemic years appeared to have less severe disease than patients with A(H1N1) pdm09 during the pandemic year. The reasons for this difference are likely multifactorial.
Published by Elsevier B.V.
KEYWORDS:
H1N1; Influenza; Inpatients; Pandemic; Post-pandemic period
PMID: 26370314 [PubMed - in process]