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  • H1N1 infection-induced thyroid storm
    Ann Thorac Med. 2010 Apr-Jun; 5(2): 110–112.
    doi: 10.4103/1817-1737.62475
    PMCID: PMC2883193
    H1N1 infection-induced thyroid storm
    Salim Alawi Baharoon
    Intensive Care Departments, King Saud Bin Abdulaziz, University for Health Sciences, Saudi Arabia
    Address for correspondence: Dr. Salim Baharoon, 1425, King Abdulaziz Medical City, King Fahad National Guard Hospital, P. O. Box 22490, Riyadh 11426, Saudi Arabia.
    Received January 16, 2010; Accepted March 10, 2010.
    Copyright © Annals of Thoracic Medicine
    This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract

    A thyroid storm is a life-threatening exacerbation of thyrotoxicosis, and is usually characterized by hyperthermia, tachycardia, severe agitation and altered mental status. A thyroid storm may be triggered by many causes, including systemic pulmonary infections. Delay in prompt diagnosis leads to high mortality. We present the first case of H1N1 infection triggering a thyroid storm. The delay in diagnosis because of preoccupancy with the H1N1 pandemic may have contributed to the poor outcome. When assessing cases with H1N1 infection, physicians should be more vigilant in order not to miss other important diagnoses.
    Keywords: Influenza A, H1N1, thyroid storm, infection induced thyroid dysfunction

    A thyroid storm is defined as a life-threatening exacerbation of thyrotoxicosis, and is usually characterized by hyperthermia, tachycardia, severe agitation and altered mental status.[1–3] It is a clinical emergency that, without early diagnosis and aggressive treatment, has a mortality rate as high as 20 to 30%.[1,2] The storm is usually due to a severe exacerbation of a preexisting thyrotoxicosis that leads to the failure of different organ systems, resulting in death.[4,5]

    Infections are frequently cited as a precipitant of thyroid storms in patients with thyrotoxicosis.[6,7] In this case report, we present a case of thyroid storm presenting initially as H1N1 infection.
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    Case Report

    A 31-year-old Afghani female, living in Makkah Al Mukarrama was brought by her relatives during the Hajj season in 2009 to King Abdulaziz Hospital with a three-day history of high-grade fever, vomiting, cough, expectoration and increasing shortness of breath. The family denied previous history of any illnesses, though they had lately noticed that she always felt hot. No further information was available.

    On examination in the emergency department, she was conscious but irritable. Recorded vitals in were as follows: temperature 39°C, HR 150 BPM, BP 100/55 mmHg and SaO2 98% with 4 L simple face oxygen mask. Chest examination revealed presence of few bilateral basal crackles, while neurological examination showed normal reactive pupils with no lateralization signs or neck stiffness. There was no documentation of neck stiffness on initial assessment.

    Laboratory results were as follows: white blood cell count (WBC) 37.7 × 109/L (normal range [NR], 5.0–10.0 × 109/L); hemoglobin, 12.0 g/dL (NR, 12.0–16.0 g/dL); serum glutamic oxaloacetic transaminase (AST) 33 U/L (NR, 10–35 U/L); serum glutamic pyruvic transaminase (ALT) 23 U/L (NR, 0–40 U/L); blood urea nitrogen, 12.5 mg/dL (NR, 8–20 mg/dL); creatinine, 0.9 mg/dL (NR, 0.6–1.5 mg/dL); blood sugar, 430 mg/dL (NR, 50–110 mg/dL); serum sodium, 140.9 mEq/L and urine dipstick glucose +++ Ketones ++.

    Her chest X-ray showed bilateral interstitial infiltrate. Lactic acid measurement test was not available. Blood, sputum and urine cultures were all obtained. Nasopharyngeal swab for H1N1 was also obtained.

    The patient was diagnosed with diabetic ketoacidosis and community-acquired bronchopneumonia with possible influenza A (H1N1) viral pneumonia. She was admitted to the medical ward and was started on Ceftriaxone, Clindamycine and Oseltamivir (Tamiflu). She also received insulin infusion and was given IV hydration with normal saline (NS).

    After 48 h of being in the medical ward, the medical team decided to intubate the patient because of tachypnea, hypoxia and restlessness. Her arterial blood gas (ABG) at that time was as follows: PH 7.2 PaO2 42 mmHg, pCO2 17.7 mmHg, HCO3 10.7 mEq/L. She remained in the medical ward for another 12 h until a bed could be arranged in the ICU.

    In the ICU, the first set of vitals in ICU was as follows: temperature 39°C, HR 160 and BP 95/48 mm Hg. She was ventilated on Synchronized Intermittent Mandatory Ventilation (SIMV) mode with 60% FiO2, a tidal volume (Vt) of 450 and positive end-expiratory pressure (PEEP) of 5 mm Hg. On that setting, the pulse oximetry was showing a saturation of (SaO2) 100%. A right subclavian central line was inserted and central venous pressure (CVP) monitoring was started. Her initial CVP was 8 mm Hg, she was given 6–8 L of IV fluid boluses in the first 12-h of care in the ICU and a maintenance fluid of 150–200 cc/h of NS. Inotropic support was started with norepinephrine, which was titrated to maintain systolic BP above 90 mm Hg. She was sedated with midazolam and fentanyl. She was started on piperacillin/tazobactam, and ciprofloxacin, while Tamiflu was continued. Her H1N1 PCR was reported positive within 6 h of admission to the unit.

    She remained critically ill, and after 48 h, she was still febrile with a high-grade temperature of 39.5°C despite around the clock on paracetamol. She also had sinus tachycardia with a heart rate of 130–160. Her blood pressure (BP) was fluctuating on high-dose norepinephrine, which was changed to phenylephrine and vasopressin. All cultures including sputum and blood did not grow any organisms, and despite that antibiotic was changed again in 48 h to imipenem and ciprofloxacin because of poor response to the initial regimen.

    Her FiO2 requirement, however was progressively improving and in 48 h, she was on 40% FiO2, with ABG pH 7.4 PaO2 108 mm Hg, pCO2 28 mm Hg and HCO3 20 mEq/L. The bilateral chest x-ray infiltrate was resolving.

    On the third day of admission, a thyroid function test was requested due to unexplained tachycardia. Thyroid function results were available in 24 h and were as follows Thyroid stimulating hormone TSH < 0.01 mIU/L (0.3–3.0 nmolIU/L), T3 50 nmol/L (1.1–3 nmol/L) T4 200 nmol/L (60–145 nmol/L).

    The diagnosis of thyroid storm was considered and she was started on propylthiouracil, 150 mg every 6 h (the only available drug) and on esmolol infusion. No iodine preparation was available.

    There was a significant improvement of tachycardia and hemodynamics after these measures but the patient was already progressing to multiorgan failure with progressively worsening renal and liver parameters as shown in Table 1. She was started on renal replacement therapy on the sixth day of admission. On the seventh day of admission, she suddenly became bradycardic and had a 6-min cardiac arrest. The patient's pupils were fixed and dilated after cardiopulmonary resuscitation. A CT of the brain was requested; it revealed a massive subarachnoid hemorrhage with severe brain edema. Despite aggressive measures that included Mannitol and hyperventilation, she progressed to brain death and was pronounced dead on the ninth day of admission to the hospital.
    Table 1
    Table 1
    Laboratory values during admission
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    For a long time, researchers have been interested in infection as a factor in the pathogenesis of thyroid illness. Valtonen et al. measured a broad spectrum of bacterial and viral antibodies in paired sera of 32 patients with thyroid disease of recent onset including subacute thyroiditis, Graves' disease and Hashimoto's disease and found evidence of a preceding infection in 44% of the patients. Preceding bacterial infections were more common than viral infections in those samples.[7]

    Infections are frequently cited as a potential precipitating factor of thyroid storms. Direct involvement of the thyroid gland (suppurative thyroiditis) with acute or subacute infection can precipitate a crisis.[8] However, the mechanism for precipitating a crisis in systemic illness is not well understood. It is well documented that the stress of systemic infections such as respiratory infections, endocarditis and urinary tract infections can precipitate a crisis.[9–13] Some researchers found acceleration of thyroxine and triiodothyronine turnover during systemic infection; this finding may partially explain the thyroid dysfunction during systemic illness,[14] Wolf et al. studied the sera of patient recovering from Yersinia enterocolitica infections and observed that the immunoglobulins of these patients exhibited Graves' disease-like activity in human thyroid membranes.[15]

    Infections of viruses, including the hepatitis C, hepatitis B and Epstein–Barr virus infection were associated with increased incidence of clinical and subclinical autoimmune thyroiditis, which may represent an Immunmodulation phenomenon.[16,17] Alteration of thyroid hormones has also been observed in HIV infection especially at advanced stages.[18,19]

    While the parainfluenza virus has previously been associated with one case of thyroid storm, neither Influenza A infection nor H1N1 strain infections has been previously cited as a precipitant for such a crisis. The fear of an H1N1 infection pandemic that occurred through out 2009 has caused much confusion, sometimes leading to delay in the diagnosis of some important illnesses and to misclassification of patient under the umbrella of H1N1 infection. The diagnosis of thyroid storm was delayed in our case because of the emphasis on H1N1 infection.

    This case highlights the very important fact that physicians should be very vigilant when evaluating cases of H1N1 infection and should consider other diagnoses. Unfortunately, our patient progressed to multi-organ failure, which is a well-known complication of thyroid storm. To our knowledge, subarachnoid hemorrhage has not been reported as a complication of thyroid storm. Transient disturbances in consciousness level, central sinus venous thrombosis and bilateral ganglia infarct all have all been reported previously.[20–22] A distinct entity of high-attenuation areas appearing in the CT scans of patients after cardiac arrest (called pseudo-subarachnoid hemorrhage) has been reported in literature; this may be the finding in our patient. This type of hemorrhage is seen in post-cardiac arrest patients and is associated with severe brain edema and poor outcome.[23]
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    This is the first case of H1N1 induced thyrotoxicosis that we are aware of. The case presented here illustrates how the obsession with H1N1 infection can potentially delay the diagnosis of other critical illnesses and adversely affect the outcome.
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    Source of Support: Nil

    Conflict of Interest: None declared.

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    7. Valtonen VV, Ruutu P, Varis K, Ranki M, Malkamäki M, Mäkelä PH. Serological evidence for the role of bacterial infections in the pathogenesis of thyroid diseases. Acta Med Scand. 1986;219:105–11. [PubMed]
    8. Al-Kordi RS, Alenizi E, Elgazzar AH. Acute suppurative thyroiditis with abscess, gas formation, and thyrotoxic crisis. Nuklearmedizin. 2008;47:N44–6. [PubMed]
    9. Jampen C, Müller B, Weiss M. 49-year-old patient with staphylococcal endocarditis and thyrotoxic crisis. Praxis (Bern 1994) 2003;92:1261–4. [PubMed]
    10. Yoshie T, Masao Y, Masaya I, Ken S, Hideyuki K. Thyroid crisis caused by respiratory infection, twenty-six years after the onset of Graves' disease-a case report. J Okayama Saiseikai Gen Hospital. 2004;36:34–8.
    11. Bečejac B, Vrkljan M, Solter M, Sikirica N. Thyrotoxic crisis in a 75 years old woman. Acta Clin Croat. 2003;42:229–31.
    12. Rufener S, Arunachalam V, Ajluni R, Sil A. Thyroid storm precipitated by infection: An atypical case involving multisystem organ dysfunction. Endocrinologist. 2005;15:111–4.
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    14. Gregerman RI, Solomon N. Acceleration of thyroxine and triiodothyronine turnover during bacterial pulmonary infections and fever: implications for the functional state of the thyroid during stress and in senescence. J Clin Endocrinol Metab. 1967;27:93–105. [PubMed]
    15. Wolf MW, Misaki T, Bech K, Tvede M, Silva JE, Ingbar SH. Immunoglobulins of patients recovering from Yersinia enterocolitica infections exhibit Graves' disease-like activity in human thyroid membranes. Thyroid. 1991;1:315–20. Winter. [PubMed]
    16. Tomer Y. Hepatitis C and interferon induced thyroiditis. J Autoimmun. 2010;34:J322–6. [PMC free article] [PubMed]
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    Articles from Annals of Thoracic Medicine are provided here courtesy of Medknow Publications
    __________________________________________________ _______________________________
    "Well, now." Mr. Summers said soberly, "guess we better get started, get this over with, so's we can go
    back to work. Anybody ain't here?" ---The Lottery by Shirley Jackson

    “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed

    (My posts are not intended as advice or professional assessments of any kind.)
    Never forget Excalibur.

  • #2
    Re: H1N1 infection-induced thyroid storm

    Another report from the same year:
    Endocrine Abstracts (2010) 22 P194
    Thyroid storm accompanied by H1N1 influenza infection
    Ayten Oguz1, Reyhan Ersoy1, Rahmet Guner2 & Bekir Cakir1
    1Department of Endocrinology and Metabolism, Ankara Ataturk Education and Research Hospital, Ankara, Turkey; 2Department of Infectious Diseases and Clinical Microbiology, Ankara Ataturk Education and Research Hospital, Bilkent, Ankara, Turkey.

    Case report: A 56-year-old woman admitted to emergency department with fever, dyspnea, productive cough, palpitations, diffuse myalgia, and malasia. Physical examination revealed an anxious-appearing woman with fine tremor in the hands. Her pulse was 140 beats/minute and irregular; blood pressure, 140/90 mmHg; temperature 38.6 °C, respiratory rate 40 breaths per min, and oxygen saturation 91% without supplemental oxygen. In auscultation, bilaterally rales and bronchial breath sounds were heard. Chest radiography at admission showed bilaterally patchy pneumonia. The leukocyte count was 3.400/μl with 45% polymorphonuclear cells, 50% lymphocytes and 5% monocytes. In physical examination, her thyroid gland was enlarged diffusely and non tender. Electrocardiogram showed a trial fibrillation with a rapid ventricular response. Because of her symptoms and the findings on the physical examination, laboratory tests for thyroid function were done. The test revealed a decreased level of thyroid-stimulating hormone, an elevated level of free thyroxine, and free triiodothyronine. The patient’s condition continued to worsen, and she was admitted to the intensive care unit for further evaluation and management. Propylthiouracil, propranolol, and supportive therapy were started. Nasopharyngeal-swab samples were taken for influenza H1N1 virus. On day 4 of admission, samples were positive for influenza H1N1 virus by PCR. No other organisms were detected from blood, urine or respiratory tract. A 5 days course of oseltamivir was added to the therapy. The diagnosis was thyroid storm accompanied by H1N1 influenza infection. After 12 days, patient’s levels of thyroid hormones had decreased, vital signs returned to completely normal.

    Conclusion: Thyroid storm is a rare and life- threatening endocrinologic emergency that may be precipitated by trauma, surgery, systemic illness, particularly infection and sepsis. We think that, our patient highlights the potential impact of H1N1 influenza infection for thyrotoxic patients.
    __________________________________________________ _______________________________
    "Well, now." Mr. Summers said soberly, "guess we better get started, get this over with, so's we can go
    back to work. Anybody ain't here?" ---The Lottery by Shirley Jackson

    “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed

    (My posts are not intended as advice or professional assessments of any kind.)
    Never forget Excalibur.


    • #3
      Re: H1N1 infection-induced thyroid storm

      Another case, though this is 'subacute thyroiditis' rather than 'thyroid storm', they may have similar mechanisms (autoimmune?) - the statement that this was the first case ever reported of concurrent thyroiditis and influenza infection indicates this was at least a very rare event prior to pH1N1.

      Subacute thyroiditis in the course of novel H1N1 influenza infection
      Last edited by Emily; June 12, 2014, 09:21 PM. Reason: Linked to existing post on subacute case
      __________________________________________________ _______________________________
      "Well, now." Mr. Summers said soberly, "guess we better get started, get this over with, so's we can go
      back to work. Anybody ain't here?" ---The Lottery by Shirley Jackson

      “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed

      (My posts are not intended as advice or professional assessments of any kind.)
      Never forget Excalibur.