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Emerg Infect Dis
. 2024 Jul;30(7):1410-1415.
doi: 10.3201/eid3007.240480.
Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023-February 2024
Mira C Patel, Ha T Nguyen, Philippe Noriel Q Pascua, Rongyuan Gao, John Steel, Rebecca J Kondor, Larisa V Gubareva
Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.
Keywords: H1N1; Influenza; United States; antimicrobial resistance; antiviral; baloxavir; influenza A(H1N1)pdm09; neuraminidase inhibitors; oseltamivir; pH1N1; phenotypic testing; reduced inhibition; substitution; viruses.
. 2024 Jul;30(7):1410-1415.
doi: 10.3201/eid3007.240480.
Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023-February 2024
Mira C Patel, Ha T Nguyen, Philippe Noriel Q Pascua, Rongyuan Gao, John Steel, Rebecca J Kondor, Larisa V Gubareva
- PMID: 38916572
- DOI: 10.3201/eid3007.240480
Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.
Keywords: H1N1; Influenza; United States; antimicrobial resistance; antiviral; baloxavir; influenza A(H1N1)pdm09; neuraminidase inhibitors; oseltamivir; pH1N1; phenotypic testing; reduced inhibition; substitution; viruses.