Antiviral Flavonoid-Type C-Glycosides from the Flowers of Trollius chinensis

[Mingus]

http://www3.interscience.wiley.com/c...TRY=1&SRETRY=0

Research Article
<TABLE width="100%"><TBODY><TR><TD>Antiviral Flavonoid-Type C-Glycosides from the Flowers of Trollius chinensis

</TD></TR><TR><TD>Shao-Qing Cai<SUP> 1 *</SUP>, Rufeng Wang<SUP> 1</SUP>, Xiuwei Yang<SUP> 1 *</SUP>, Mingying Shang<SUP> 1</SUP>, Chaomei Ma<SUP> 1</SUP>, Yukihiro Shoyama<SUP> 2</SUP></TD></TR><TR><TD><SUP>1</SUP>The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China (phone/fax: +86-10-8280-1693)
<SUP>2</SUP>Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan
</TD></TR><TR><TD>email: Shao-Qing Cai (sqcai@bjmu.edu.cn) Xiuwei Yang (xwyang@bjmu.edu.cn)</TD></TR></TBODY></TABLE>
<SUP>*</SUP>Correspondence to Shao-Qing Cai, <SUP>1</SUP>The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China (phone/fax: +86-10-8280-1693)

<SUP>*</SUP>Correspondence to Xiuwei Yang, <SUP>1</SUP>The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China (phone/fax: +86-10-8280-1693)

<SCRIPT language=JavaScript>setDOI("ADOI=10.1002/cbdv.200690037")</SCRIPT>
<TABLE width="100%" border=0><TBODY><TR><TD class=mainSectionHeader>Keywords</TD></TR></TBODY></TABLE><TABLE><TBODY><TR><TD>Trollius chinensis ? Flavonoids ? Antiviral activity ? Trollisin ? Isoswertisin derivative ? Vitexin derivative ? Glycosides</TD></TR></TBODY></TABLE>
<TABLE width="100%" border=0><TBODY><TR><TD class=mainSectionHeader>Abstract</TD></TR></TBODY></TABLE><TABLE width="100%" border=0><TBODY><TR><TD>Two new flavonoid-type C-glycosides, trollisin I (=(1S)-1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4-oxo-4H-[1]benzopyran-8-yl]-2-O-(2-methylbutanoyl)-D-glucitol; 1) and its 2-O-benzoyl congener trollisin II (2), were isolated from Trollius chinensis Bunge, together with the two known compounds 2-O-(2-methylbutanoyl)isoswertisin (3) and vitexin galactoside (4). All compounds were identified by HR-ESI-MS and in-depth NMR-spectroscopic analyses. In antiviral assays, compound 3 was found to be moderately active towards influenza virus A.</TD></TR></TBODY></TABLE><HR align=left width="25%" SIZE=1>Received: 24 October 2005
<TABLE width="100%" border=0><TBODY><TR><TD class=mainSectionHeader>Digital Object Identifier (DOI)</TD></TR></TBODY></TABLE>
10.1002/cbdv.200690037



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[Mingus]

Re: Antiviral Flavonoid-Type C-Glycosides from the Flowers of Trollius chinensis

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[Gert van der Hoek]

Re: Antiviral Flavonoid-Type C-Glycosides from the Flowers of Trollius chinensis

Titre du document / Document title

Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge

Auteur(s) / Author(s)

LI Yao-Lan (1 2) ; MA Shuang-Cheng (2) ; YANG Yi-Ting (1) ; YE Shao-Ming (1) ; BUT Paul Pui-Hay (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Chemistry, Jinan University, Guangzhou, CHINE

(2) Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., HONG-KONG

R&#233;sum&#233; / Abstract

The flower of Trollius chinensis Bunge is used for treating upper respiratory infections, pharyngitis, tonsillitis, and bronchitis in Chinese folk medicine.

The antiviral activities of the crude extract, total flavonoids, orientin, vitexin and proglobeflowery acid isolated from the flowers of T. chinensis against parainfluenza type 3 (Para 3) virus were investigated.

The results showed that the crude extract and total flavonoids exhibited a weak antiviral activity against Para 3.

Orientin and vitexin demonstrated potent or moderate antiviral activity against Para 3. Proglobeflowery acid showed weak antiviral activity against Para 3.

Revue / Journal Title

Journal of ethnopharmacology (J. ethnopharmacol.) ISSN 0378-8741
CODEN JOETD7

Source / Source

2002, vol. 79, no3, pp. 365-368 (12 ref.)

Langue / Language
Anglais

Editeur / Publisher
Elsevier, Shannon, IRLANDE (1978) (Revue)

http://cat.inist.fr/?aModele=afficheN&cpsidt=13532508

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11849843&dopt=Abstract

[Gert van der Hoek]

Re: Antiviral Flavonoid-Type C-Glycosides from the Flowers of Trollius chinensis

Titre du document / Document title

A bioactive alkaloid from the flowers of Trollius chinensis

Auteur(s) / Author(s)

RU FENG WANG ; XIU WEI YANG ; CHAO MEI MA ; SHAO QING CAI ; JIAN NONG LI ; SHOYAMA Yukihiro ;

R?sum? / Abstract

A new compound, named as trolline was isolated from the ethanol extract of the flowers of Trollius chinensis Bunge.

The chemical structure of this compound was elucidated by NMR, MS, IR, UV spectra and single-crystal X-Ray analysis.

The in vitro antibacterial and antiviral experiments revealed that trolline exhibited appreciable antibacterial activity against respiratory bacteria such as Staphylococcus aureus, Streptococcus pneumoniae and Klebsiella pneumoniae.

Trolline was also demonstrated to have moderate antiviral activity against influenza virus A and B.

Revue / Journal Title
Heterocycles (Heterocycles) ISSN 0385-5414 CODEN HTCYAM
Source / Source
2004, vol. 63, no6, pp. 1443-1448 [6 page(s) (article)]
Langue / Language
Anglais

Editeur / Publisher
Elsevier, Oxford, ROYAUME-UNI (1973) (Revue)

http://cat.inist.fr/?aModele=afficheN&cpsidt=15798714

[gsgs]

Re: Antiviral Flavonoid-Type C-Glycosides from the Flowers of Trollius chinensis

"moderate" doesn't sound very promising, does it ?

What's with these polyphenols as in elderberries etc.,
have they been chemically classified or isolated ?

I remember, a Singapore company would sell those
elderberry pills in Jan.

[Shannon Bennett]

Re: Antiviral Flavonoid-Type C-Glycosides from the Flowers of Trollius chinensis

While this may eventually provide the framework for an antiviral, I want to remind our readers that trollius is extremely toxic taken in its fresh or dried form. Do not use this as an antidote to any illness!

[AlaskaDenise]

Re: Antiviral Flavonoid-Type C-Glycosides from the Flowers of Trollius chinensis

Thanks for that important tidbit, Shannon.

.