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J Clin Microbiol. 2012 Apr 25. [Epub ahead of print]
Recovery of Influenza B Virus with the H273Y Point Mutation in the neuraminidase Active site from a Human Patient.
Higgins RR, Beniprashad M, Chong-King E, Li Y, Bastien N, Low DE, Gubbay JB.
Source
Public Health Ontario, 81 Resources Road, Toronto M9P 3T1, Canada.
Abstract
The H275Y oseltamivir resistance mutation confers high level resistance to oseltamivir in isolates of human A/H1N1 influenza. We report the recovery and identification of an influenza B virus with the H273Y neuraminidase point mutation directly from a human patient. The H273Y influenza B isolate is resistant to oseltamivir and peramivir but sensitive to zanamivir.
PMID:
22535992
[PubMed - as supplied by publisher]
Recovery of Influenza B Virus with the H273Y Point Mutation in the neuraminidase Active site from a Human Patient.
Higgins RR, Beniprashad M, Chong-King E, Li Y, Bastien N, Low DE, Gubbay JB.
Source
Public Health Ontario, 81 Resources Road, Toronto M9P 3T1, Canada.
Abstract
The H275Y oseltamivir resistance mutation confers high level resistance to oseltamivir in isolates of human A/H1N1 influenza. We report the recovery and identification of an influenza B virus with the H273Y neuraminidase point mutation directly from a human patient. The H273Y influenza B isolate is resistant to oseltamivir and peramivir but sensitive to zanamivir.
PMID:
22535992
[PubMed - as supplied by publisher]
