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Antibiot Khimioter. 2011;56(5-6):3-6.
[Investigation of antiviral activity of adamantan boron derivaties on pandemic influenza virus models].
[Article in Russian]
[No authors listed]
Abstract
Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. The minimum inhibitory concentration (MIC) of the products was 0.1 mcg/ml. The use of liposomes loaded with BG 12 molecules in the optimal concentration (0.1 mcg/ml) resulted in inhibition of the avian plague virus growth in the MDCK cells. Possible design of efficient drugs for antiviral protection based on the complexes liposomes--boron-containing compounds is discussed.
PMID:
22145224
[PubMed - in process]
[Investigation of antiviral activity of adamantan boron derivaties on pandemic influenza virus models].
[Article in Russian]
[No authors listed]
Abstract
Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. The minimum inhibitory concentration (MIC) of the products was 0.1 mcg/ml. The use of liposomes loaded with BG 12 molecules in the optimal concentration (0.1 mcg/ml) resulted in inhibition of the avian plague virus growth in the MDCK cells. Possible design of efficient drugs for antiviral protection based on the complexes liposomes--boron-containing compounds is discussed.
PMID:
22145224
[PubMed - in process]
