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Dose-Response Time Modeling for Highly Pathogenic Avian Influenza A (H5N1) Virus Infection
Masaaki Kitajima1,*,
Yin Huang2,
Toru Watanabe3,
Hiroyuki Katayama4,
Charles N. Haas5
DOI: 10.1111/j.1472-765X.2011.03128.x
Copyright ? 2011 The Society for Applied Microbiology
ABSTRACT
Aims: To develop time-dependent dose-response models for highly pathogenic avian influenza A (HPAI) of the H5N1 subtype virus.
Methods and Results: A total of four candidate time-dependent dose-response models were fitted to four survival data sets for animals (mice or ferrets) exposed to graded doses of HPAI H5N1 virus using the maximum likelihood estimation. A beta-Poisson dose-response model with the N50 parameter modified by an exponential-inverse-power time dependency or an exponential dose-response model with the k parameter modified by an exponential-inverse time dependency provided a statistically adequate fit to the observed survival data.
Conclusions: We have successfully developed the time-dependent dose-response models to describe mortality of animals exposed to an HPAI H5N1 virus. The developed model describes the mortality over time and represents observed experimental responses accurately.
Masaaki Kitajima1,*,
Yin Huang2,
Toru Watanabe3,
Hiroyuki Katayama4,
Charles N. Haas5
DOI: 10.1111/j.1472-765X.2011.03128.x
Copyright ? 2011 The Society for Applied Microbiology
ABSTRACT
Aims: To develop time-dependent dose-response models for highly pathogenic avian influenza A (HPAI) of the H5N1 subtype virus.
Methods and Results: A total of four candidate time-dependent dose-response models were fitted to four survival data sets for animals (mice or ferrets) exposed to graded doses of HPAI H5N1 virus using the maximum likelihood estimation. A beta-Poisson dose-response model with the N50 parameter modified by an exponential-inverse-power time dependency or an exponential dose-response model with the k parameter modified by an exponential-inverse time dependency provided a statistically adequate fit to the observed survival data.
Conclusions: We have successfully developed the time-dependent dose-response models to describe mortality of animals exposed to an HPAI H5N1 virus. The developed model describes the mortality over time and represents observed experimental responses accurately.
