Check out the FAQ,Terms of Service & Disclaimers by clicking the
link. Please register
to be able to post. By viewing this site you are agreeing to our Terms of Service and Acknowledge our Disclaimers.
FluTrackers.com Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster.
The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website.
By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website.
We are not asking for any donations. Do not donate to any entity who says they are raising funds for us.
Announcement
Collapse
No announcement yet.
PAHO rejects report of resistant H1N1 cases on US-Mexico border
Is that the same number they pulled out when resistant H5N1 1st showed up in Egypt?
.
The number is based on resistance years ago (primarily in H3N2) in children in Japan who were given sub-optimal levels of Tamiflu. The number of recent (since 2006) H3N2 sequences with Tamiflu resistance is ZERO and the vast majority of H1N1 cases with H274Y were NOT treated with Tamiflu.
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border
I think the title change for this thread is misleading. It is likely that PAHO is trying to "pull back" the story by splitting hairs and taking a position that the detection of H274Y is only "diagnostic" and the samples have not been formally tested for resistance, which is just an excuse to delay/withhold the information on the multiple cases of Tamiflu resistance that have been found, as indiacted in the original title.
PAHO rejects report of resistant H1N1 cases on US-Mexico border
Cerqueira said she repeated several times that she had no information on any antiviral-resistant cases in the border area. "It is an unfortunate misinterpretation that needs to be clarified," she wrote.
She wrote that she has heard about two antiviral-resistant cases from a physician in Colombia, but that the source did not say they were near the US-Mexico border.
These comments are still not adding up. There are confirmed H1N1 cases at multiple locations along the Texas / Mexico border, including deaths at multiple locations (see map)
and cross traffic with Mexico would include Arizona and California, where there are also multiple locations with confirmed cases and deaths on both sides of tborder, so the singling out of two locations in Texas of areas of increased concnern, without reports of Tamiflu resistance, makes little sense. Moreover, the description of the two cases specifically mentions diagnositic resistance, and the presence of H274Y is frequently considered diagnostic for resistance when samples are not formally tested for resistance. At Genbank, sequences with H274Y are labeled with and astrisk with the following warning
* This sequence has the H274Y mutation that might confer resistance to Oseltamivir.
Since it is well known that N1 with H274Y confers resistance in the range of 300-1000 (takes 300 to 1000X the amount of Tamiflu to acheive the same level of inhibition seen in wild type), the presence of H274Y is considered "diagnostic" of resistance (which is confirmed when such samples are directly tested with multiple concentrations of Tamiflu).
Thus, the confusion may simply be PAHO clinging to the absence of formal testing as an excuse for stating there is "no data" on resistance becasue there has been no direct resistance testing (which is only done at a handful of locations world wide - the Tamiflu resistance in Egypt, indicated by another polymorphisms linked to resistance, S294N, was "confirmed" in Atlanta by the CDC, which showed that the S294N confered the same resistance (10-20 fold) previously reported for this genetic change in other isolates.
The subsequent reports of 6 cases of resistance suggest the original remarks of resistance on the Texas / Mexico story were accurate, current "rejection reports" notwithstanding.
PAHO rejects report of resistant H1N1 cases on US-Mexico border
Lisa Schnirring * Staff Writer
Cerqueira said she repeated several times that she had no information on any antiviral-resistant cases in the border area. "It is an unfortunate misinterpretation that needs to be clarified," she wrote.
"No information ON any antiviral cases" can simply indicate a lack of clinical details (i.e. if and when patients were treated with Tamiflu) which is distinct from "no information OF any antiviral case".
I think the title change for this thread is misleading. It is likely that PAHO is trying to "pull back" the story by splitting hairs and taking a position that the detection of H274Y is only "diagnostic" and the samples have not been formally tested for resistance, which is just an excuse to delay/withhold the information on the multiple cases of Tamiflu resistance that have been found, as indiacted in the original title.
Agreed. The way in which this was retracted doesn't quite pass the smell test to me. Conflicting reports, perhaps?
Wotan (pronounced Voton with the ton rhyming with on) - The German Odin, ruler of the Aesir.
I am not a doctor, virologist, biologist, etc. I am a layman with a background in the physical sciences.
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border
No Tamiflu Resistant Swine Flu Cases On Mexico/US Border -WHO
ZURICH -(Dow Jones)- The World Health Organization hasn't observed any cases of resistance against the swine flu antiviral drug Tamiflu along the U.S./ Mexican border, WHO spokeswoman Aphaluck Bhatiasevi said Wednesday.
The remarks are in response to a press report quoting WHO Chief Medical Officer Maria Teresa Cerqueira as saying WHO had observed cases of the A/H1N1 swine flu virus along the border between the U.S. and Mexico that have shown a resistance to Roche Holding AG's (ROG.VX) antiviral drug Tamiflu.
"The chief medical officer was misquoted," said Bhatiasevi. "She had said that there are cases of the H1N1/A virus along the border and that the WHO recommends surveying those cases in case a potential resistance occurs. But currently there are no cases of resistance along the border," Bhatiasevi said.
She added that a total of six cases in four countries have shown a resistance to Tamiflu, but that that's a "small number of isolated cases."
The countries are Denmark, Hong Kong, Japan and Canada, according to information on the WHO's web site.
Tweet
We may have to make you a Texas Ranger.
Comment