Changes in the influenza virus that creates painful symptoms

[Shiloh]

Source: http://www.infobae.com/contenidos/45...-s%C3%ADntomas

Google translation:

Changes in the influenza virus that creates painful symptoms


Hospital director Malvinas Argentinas, Graciela Bonfigli, C5N explained that patients who are now in serious condition suffering from acute renal failure and hematologic disorders


Graciela Bonfigli, director of the Hospital Malvinas Argentinas, instead aiming only to patients who have the virus AH1N1 spoke exclusively with C5N and explained that, in very serious cases, two new diseases in patients.

According to the doctor, the influenza A virus affects more than a common flu because it brings additional tables.

Those who are in serious condition for being victims of the virus AH1N1 Two new symptoms that were not being taken into account. The first is acute renal failure, which has to be helped by dialysis. The second consequence is the occurrence of hematological abnormalities, such as when blood clots form throughout the body.

Bonfigli explained that may not yet have an explanation because the virus continues to mutate constantly. Furthermore argued that if patients have no prior history, they are generally healthy adults who have a fall with pneumonia and respiratory failure. "

Measures by the Government, all health personnel will be pre-medicated because they are in permanent contact with the sick.

[wotan]

Re: Changes in the influenza virus that creates painful symptoms

We really need to get sequences from Argentina to see if there are some important changes to the virus going on down there.

[kent nickell]

Re: Changes in the influenza virus that creates painful symptoms

This article highlights how cytokine storm can lead to both DIC (disseminated intravascular coagulation) and MOF (multiple organ failure) making these patients especially difficult to treat.. (this article relates one mechanism of instigating a cytokine storm)

1: Pediatr Int. 2000 Apr;42(2):197-203. Links

http://www.ncbi.nlm.nih.gov/pubmed/10804742

Hypothetical pathophysiology of acute encephalopathy and encephalitis related to influenza virus infection and hypothermia therapy.

Yokota S, Imagawa T, Miyamae T, Ito S, Nakajima S, Nezu A, Mori M.

Department of Pediatrics, Yokohama City University School of Medicine, Kanagawa, Japan. syokota@med.yokohama-cu.ac.jp

BACKGROUND: To establish a treatment strategy for acute encephalopathy and encephalitis associated with influenza virus infection, the pathophysiology of the disease was investigated through manifestations and laboratory findings of patients. PATIENTS AND METHODS: A child with central nervous system (CNS) complications during the course of influenza virus infection was analyzed in view of immunologic abnormalities. In addition, four children with acute encephalopathy and encephalitis were enrolled in the hypothermia treatment for the purpose of stabilizing the cytokine storm in the CNS. RESULTS: The CNS symptoms preceded the systemic progression to the failure of multiple organs (MOF) and disseminated intravascular coagulopathy (DIC). The mild hypothermia suppressed the brain edema on computed tomography (CT) scanning and protected the brain from the subsequent irreversible neural cell damage. CONCLUSION: The replicated viruses at the nasopharyngeal epithelium may disrupt the olfactory mucosa and gain access to the brain via the olfactory nerve system. The direct virus-glial cell interaction or viral stimulation of the glial cells induces the production and accumulation of the pro-inflammatory cytokines, especially tumor necrosis factor (TNF)-alpha, in the CNS. The cytokine storm results in neural cell damage as well as the apoptosis of astrocytes, due to the TNF-alpha-induced mitochondrial respiratory failure. The disruption of the blood-brain barrier progresses to the systemic cytokine storm, resulting in DIC and MOF. Mild hypothermia appears promising in stabilizing the immune activation and the brain edema to protect the brain from ongoing functional, apoptotic neural and glial damage and the systemic expansion of the cytokine storm.

[marcovth]

Re: Changes in the influenza virus that creates painful symptoms

The people who died in Mexico in April, did they have similar symptoms, or is this a new development?

[tropical]

Re: Changes in the influenza virus that creates painful symptoms

#1:
"the virus continues to mutate constantly. Furthermore argued that if patients have no prior history, they are generally healthy adults who have a fall with pneumonia and respiratory failure. "

Measures by the Government, all health personnel will be pre-medicatedbecause they are in permanent contact with the sick." <!-- / message -->

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[kent nickell]

Re: Changes in the influenza virus that creates painful symptoms

It seems hard to tell in Mexico if people were waiting to be seen until they turned very bad and maybe the same thing in Argentina. Some patients in both countries as well as the US appear to have a rapid severe course. In Mexico there was evidence of DIC as well as other systemic signs such as low blood pressure and MOF. Elevated D-dimer is a measure of DIC (and not necessarily a commonly done test) (Four patients in Mexico had D-dimer levels greater than 1000 IU per liter http://content.nejm.org/cgi/content/full/NEJMoa0904252 )

We need to watch for clusters of severe cases and try and determine the best we can how their disease progressed and what treatments are working or not working...