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MERS-CoV, Qatar (OIE, April 22 2014): Camel w/ human replication ability virus detected in a farm

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  • MERS-CoV, Qatar (OIE, April 22 2014): Camel w/ human replication ability virus detected in a farm

    [Source: OIE, full page: (LINK). Edited.]


    MERS-CoV, Qatar


    Information received on 22/04/2014 from Dr Kassem Nasser Al-Qahtani, Director of Dept of Animal resources, Ministry of Environment, Department of Animal resources, DOHA, Qatar
    • Summary
      • Report type Follow-up report No. 2
      • Date of start of the event 14/10/2013
      • Date of pre-confirmation of the event 26/11/2013
      • Report date 22/04/2014
      • Date submitted to OIE 22/04/2014
      • Reason for notification Emerging disease
      • Morbidity 3.8 %
      • Mortality 0 %
      • Zoonotic impact Asymptomatic exposure of camel to MERS-CoV (laboratory advanced) and one outbreak in a specific zone (Shahanya)
      • Causal agent MERS-CoV
      • Related reports
        • Immediate notification (28/11/2013)
        • Follow-up report No. 1 (29/12/2013)
        • Follow-up report No. 2 (22/04/2014)

    • New outbreaks (1)
      • Outbreak 1 - Al-Shahanya, AR RAYYAN
        • Date of start of the outbreak 11/02/2014
        • Outbreak status Continuing (or date resolved not provided)
        • Epidemiological unit Farm
        • Affected animals: Species Susceptible Cases Deaths Destroyed Slaughtered
          • Camelidae - 26 1 0 0 0
          • Affected population A single barn of 26 camels of different ages.

    • Summary of outbreaks
      • Total outbreaks: 1
        • Total animals affected: Species Susceptible Cases Deaths Destroyed Slaughtered
          • Camelidae 26 1 0 0 0

        • Outbreak statistics: Species - Apparent morbidity rate - Apparent mortality rate - Apparent case fatality rate - Proportion susceptible animals lost*
          • Camelidae - 3.85% - 0.00% - 0.00% - 0.00%
          • *Removed from the susceptible population through death, destruction and/or slaughter

    • Epidemiology
      • Source of the outbreak(s) or origin of infection
        • Unknown or inconclusive

    • Epidemiological comments
      • During an existing survey (pilot phase of the survey), nasal swabs were collected from an 8-month-old camel among healthy dromedary camels.
      • The sample was inoculated on Vero cells and cytopathic changes were observed in cells at 48h post-infection.
      • Human hepatoma cells (Huh-7 cells) were inoculated with MERS-CoV to further functionally characterize this viral isolate.
      • After two days, virus-induced cytopathic effects were observed in the inoculated cell cultures.
      • Virus production in Huh-7 cells was blocked by pre-incubating MERS-CoV with a 1/200 dilution of serum from MERS-CoV antibody positive camels.
      • Conclusion: these data demonstrate that the MERS-CoV obtained from a dromedary camel is able to replicate in human cells and uses DPP4 as entry receptor, similar as isolates obtained from MERS patients.

    • Control measures
      • Measures applied
        • No vaccination
        • No treatment of affected animals

      • Measures to be applied
        • Quarantine
        • Movement control inside the country
        • Screening

    • Diagnostic test results
      • Laboratory name and type Species Test - Test date Result
        • Department of Viroscience, Erasmus Medical Center, Rotterdam (The Netherlands) (Foreign laboratory) Camelidae - real-time PCR - 19/04/2014 Positive
        • Department of Viroscience, Erasmus Medical Center, Rotterdam (The Netherlands) (Foreign laboratory) Camelidae - virus isolation - 19/04/2014 Positive

    • Future Reporting
      • The event is continuing. Weekly follow-up reports will be submitted.

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  • #2
    Re: MERS-CoV, Qatar (OIE, April 22 2014): Camel w/ human replication ability virus detected in a farm

    One hopes a camel vaccine will be developed ASAP given the ramifications.
    Please do not ask me for medical advice, I am not a medical doctor.

    Avatar is a painting by Alan Pollack, titled, "Plague". I'm sure it was an accident that the plague girl happened to look almost like my twin.
    Thank you,
    Shannon Bennett

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