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Early release October 2024
Abstract
Respiratory syncytial virus (RSV) is a leading cause of illness in infants (1). Previous epidemiologic studies of RSV infection during infancy have focused on symptomatic illness, predominantly lower respiratory tract infections (LRTI) and hospitalizations (2). However, population-based surveillance studies to determine prevalence of and risk factors for RSV infection among healthy infants in the United States are lacking
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In conclusion, our data are important estimates of the burden of RSV disease and risk factors for infection in healthy term infants. Our findings provide a benchmark to monitor the effects in the United States of recently available maternal vaccines and extended half-life monoclonal antibodies for severe RSV illness prevention in early life (10).
Abstract
In a population-based birth cohort study of respiratory syncytial virus surveillance in the United States, 897/1,680 (53.4%) children were infected during infancy; 25/897 (2.8%) were hospitalized. Among symptomatic infants, 143/324 (44.1%) had lower respiratory tract infections. These data provide benchmarks to monitor effects of maternal vaccines and extended half-life monoclonal antibodies.
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In conclusion, our data are important estimates of the burden of RSV disease and risk factors for infection in healthy term infants. Our findings provide a benchmark to monitor the effects in the United States of recently available maternal vaccines and extended half-life monoclonal antibodies for severe RSV illness prevention in early life (10).