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Indonesia H5N1 Ginting family cluster in Bandung - 05/24 - 05/27, 2006

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  • #46
    Re: Indonesia 5/24

    Bird flu team 'too late'
    From: The Australian
    By Clara Pirani

    May 26, 2006


    DELAYS in the investigation of the world's largest outbreak of bird flu may prevent health officials from ever knowing if human-to-human transmission of the disease killed six members of the same family in Indonesia.

    A team of the world's leading avian flu experts has arrived in the remote village of Kubu Sembelang in North Sumatra to investigate the deaths, which occurred during the past three weeks.

    However, the director of the World Health Organisation's Collaborating Centre for Reference and Research on Influenza in Melbourne, Ian Gust, said most of the evidence would already have been destroyed.

    "We've found with the investigation of clusters in the past that by the time the investigators get there, it's too late," he said yesterday. "Any infected birds that might have been around have gone or been killed.

    "You can't take the adequate samples and you'll never know the cause, and that's a problem."

    Indonesian health officials were not responding quickly enough to potential cases of the disease, Dr Gust told The Australian.

    "Indonesia is still struggling with it. Vietnam, which had a very serious problem with bird flu, has essentially brought it under control by very vigorous health measures, whereas Indonesia is still getting lots of outbreaks in birds and lots of cases in humans," Dr Gust said.

    Vietnam reported 61 cases of bird flu last year, including 19 deaths - significantly more than any other country.

    Twenty-two people have died of bird flu in Indonesia this year while Vietnam has experienced no new cases.

    Peter Cordingley, spokesman for the WHO's West Pacific region, said investigators were concerned about the cluster of deaths in North Sumatra - the largest to date - and the source of the outbreak.

    He said they had not found any infected poultry in the village.

    "When we can't find a common outside source, we have to look at the potential for human-to-human transmission," he said.

    Infected poultry has been the source of the majority of human infections worldwide. However, the WHO suspects human-to-human transmission may have caused up to half a dozen previous clusters in recent years.

    Mr Cordingley said there was no effective test to confirm human-to-human transmission.

    "We've had very strong evidence of human-to-human transmission before, but in the end we haven't been able to draw any further conclusions, so we just don't know," he said.

    Seven members of the same family in North Sumatra contracted the disease and six have died in the past three weeks.

    An eighth family member, the first to become ill, died on May 4, but no samples were taken to confirm the cause of death.

    Two of the men who died spent the night of April 29 in a small room with their mother - the first family member to fall ill - who was reportedly coughing frequently. A third son has the disease and is the sole surviving family member.

    Another family member, a 32-year-old father, died on Monday after caring for his sick son.

    Other infected family members lived in adjacent homes.

    The H5N1 virus has killed 124 people since 2003 and more than 30 countries have reported outbreaks in poultry or wild birds.

    The WHO has previously warned that clusters of the disease are considerably more dangerous than isolated infections because they raise the possibility that the virus might have mutated, allowing it to spread rapidly among humans, and sparking a pandemic that could kill millions of people.

    However, Mr Cordingley said there was no evidence of spread within the general community with the latest cluster.

    "Nobody outside the family shows any sign of infection, so we don't have a virus on the run," he said. "The virus samples from those who died shows the virus is not mutating and it shows no new ability to mutate from chickens to humans."

    Comment


    • #47
      Re: Indonesia 5/24

      Indonesia's local test shows another bird flu cluster death

      UPDATED: 07:53, May 26, 2006

      Two people from one family, who died earlier this week in West Java province, have been tested positive to bird flu virus by a local lab, the Indonesian Health Ministry said in Jakarta Thursday.


      "They are brother and sister, both are positively infected," Director of Health and Environmental Health of the Ministry I Nyoman Kandun Kandun told Xinhua.


      However, he could not confirm whether the two had contact with fowls.
      Their blood samples have been sent to the World Health Organization affiliated laboratory for bird flu test in Hong Kong, he said.


      The death of the two came after the biggest bird flu cluster death in North Sumatra province earlier this month.


      Indonesia is probing into possible human-to-human transmission.


      Experts fear that the virus could mutate to a certain form that can easily transmit from human to human, which can kill millions of people.
      The WHO has confirmed 32 people have been killed by the highly pathogenic H5N1 virus in Indonesia.


      Source: Xinhua


      http://english.peopledaily.com.cn/20...26_268629.html

      Comment


      • #48
        Re: Indonesia 5/24

        Indonesia puts villagers on home quarantine
        Thu May 25, 2006 9:07am ET6

        JAKARTA (Reuters) - Health experts have asked 33 people in a remote Indonesian village to quarantine themselves at home after the H5N1 bird flu virus killed as many as seven members of a family there earlier this month.

        Epidemiologists have failed to track down the source of infection in Kubu Simbelang village in north Sumatra and the World Health Organization said this week limited human-to-human transmission between family members might have occurred.

        "There are 33 people identified as close contacts. We've asked them to observe home quarantine. That's something they are willing to do to protect themselves and their families," said Dick Thompson, spokesman for the WHO.

        Meanwhile, local tests have confirmed an Indonesian child from the city of Bandung died of bird flu, a senior health ministry official said on Thursday.

        Local results on bird flu cases are not considered definitive and need confirmation from the World Health Organization.

        I Nyoman Kandun, director-general of communicable disease control, told Reuters local tests have found two siblings admitted to hospital earlier this week in the West Java capital of Bandung was a positive H5N1 case.

        "The two of them are now positive," he told Reuters in a telephone text message.

        The younger sibling, a 10-year old girl, died on Tuesday. The condition of the 18-year-old brother was not immediately clear.

        But attention is still primarily focused on the Sumatran cluster, the largest to date

        Tests on samples taken from chickens, ducks and pigs -- animals that are most susceptible to the virus -- in Kubu Simbelang village and another nearby area have proven inconclusive.

        Fuelling the suspicion hanging over person-to-person transmission is the unusually long time lag of 15 days between the first and the last person in the cluster falling ill.

        The incubation period for the H5N1 is usually no more than seven days and if the family had been exposed to the same source, they would all have fallen ill at about the same time.

        "You want to look at the dates of onset of the disease. If they are close together they may have had the same exposure," Thompson said.

        The WHO has, however stressed that even if human-to-human transmission did occur, it was in a very limited way and the infection has not spread beyond the family cluster. In addition, scientific evidence has shown the virus has not mutated into one that can be easily passed among people.

        H5N1 remains difficult for humans to catch, but experts fear it could evolve into a form passes easily from human to human, causing a pandemic that could kill millions.

        Comment


        • #49
          Bird flu kills two siblings, preliminary tests find

          Bird flu kills two siblings, preliminary tests find
          May 26, 2006

          JAKARTA (AP): Preliminary tests have found that bird flu killed two more siblings in Indonesia, officials said Friday, as the country grapples with a separate outbreak involving the largest family cluster ever reported.

          Local tests found that a brother and sister from West Java who died earlier this week were infected by the H5N1 virus, said Nyoman Kandun, head of the Health Ministry's office of communicable disease control.

          The tests will be sent to a World Health Organization laboratory for further confirmation. WHO officials so far have confirmed 33 human deaths from bird flu in Indonesia, out of 124 worldwide.

          The latest victims, an 18-year-old boy and his 10-year-old sister, died Tuesday in the state-run Hasan Sidikin hospital in Bandung, the capital city of West Java, said Achmad, an official at the ministry's special task force post for bird flu, who uses only one name. They died within hours of each other less than a day after arriving at the hospital, he said.

          The newest cases come as Indonesia is struggling with a different family cluster in northern Sumatra where six of seven family members died of bird flu, the most recent on Monday. An eighth family member who died was buried before tests could be done, but she was also considered to be among those infected with bird flu.

          WHO officials have not been able to link the family members to contact with infected birds, and have said it's possible limited human-to-human transmission may have occurred. Similar isolated cases of transmission among humans is believed to have occurred in four or five other family clusters, said WHO spokesman Dick Thompson. But the Indonesia case is the largest ever reported.

          However, the WHO has stressed the virus has not mutated in any way and has shown no signs of spreading outside the family - all blood relatives who had very close contact with each other.

          A team of international health experts and villagers is closely monitoring the area where the family lived in northern Sumatra to ensure no one else experiences flu-like symptoms.

          About 30 people in the village of Kubu Sembelang have been asked to stay inside their homes and avoid close contact as a precautionary measure, Thompson said.

          Experts also are exploring whether the first woman sickened in the family may have had contact with sick or dead chickens. She also worked at a market where chickens were sold and may have used chicken feces as a garden fertilizer, WHO officials have said.

          ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

          Comment


          • #50
            Re: Indonesia 5/24

            Originally posted by AnneZ
            Indonesia puts villagers on home quarantine
            Thu May 25, 2006 9:07am ET6



            "You want to look at the dates of onset of the disease. If they are close together they may have had the same exposure," Thompson said.


            http://today.reuters.com/News/newsAr...1-ArticlePage1
            What a novel concept.

            Comment


            • #51
              ANTARA News - Number of bird flu cluster cases in RI rises to 7

              ANTARA News - Number of bird flu cluster cases in RI rises to 7

              Jakarta (ANTARA News) - Two male siblings who recently died in Bandung have tested positive for bird flu bringing the total number of cluster bird flu cases in Indonesia to seven, Health Minister Siti Fadilah Supari said here Friday.

              "An RT-PCR (Reverse Transcriptase-Polymerase Chain Reaction) test has shown the two were infected," the minister said when explaining the result of the examination on bird flu suspects As (18) and AT (10) who died at the Hasan Sadikin Hospital in Bandung, West Java, recently.

              Thus, the number of cluster bird flu cases in humans that have occurred in Indonesia since July 2005 has reached seven cases, she said.

              The seven human cluster bird flu cases were those of IS (37) and her two sons in Tangerang, RD (36) and two others in South Jakarta, Her (21) and one other in Lampung, IS (19) and one other in Pondok Aren, Tangerang, N (13) and one other, PBG family (40) in Karo district, North Sumatra, and two borthers AS and AT in Bandung, West Java.


              But the minister said that so far no epidemiological and virological studies had indicated the prevalence of human-to-human bird flu infection, though such a possibility should not be ruled out.

              "The type of virus is still the same as that of the previous case, the type is still the clayde 2 that originated from animals," she added.

              ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

              Comment


              • #52
                Re: ANTARA News - Number of bird flu cluster cases in RI rises to 7

                Anyone have more info on RD (36)

                Originally posted by Theresa42
                ANTARA News - Number of bird flu cluster cases in RI rises to 7
                The seven human cluster bird flu cases were those of IS (37) and her two sons in Tangerang, RD (36) and two others in South Jakarta, Her (21) and one other in Lampung, IS (19) and one other in Pondok Aren, Tangerang, N (13) and one other, PBG family (40) in Karo district, North Sumatra, and two borthers AS and AT in Bandung, West Java.
                <o ="">
                </o>

                Comment


                • #53
                  Re: Indonesia 5/24-5/26

                  Liputan6.com, Jakarta: Health Minister Siti Fadilah Supari acknowledged had the possibility of the spread of the bird flu virus antarmanusia in a limited way related the discovery cluster just in the Karo Regency, North Sumatra."Could spread and limited to genetic that same (relatives)," Siti words ended led the meeting of the level of the minister concerning the plague of the bird flu virus in Indonesia that was spread out in Coordinating Minister for People's Welfare's Office, Jakarta the Centre, on Friday early afternoon (26/5) [read: this Afternoon, was in a meeting Cluster Bird Flu was spread out].Despite this, from information that was assembled by SCTV, this meeting also decided that the government will put number regulations into effect 4 in 1984 about the Plague of the Illness.In the Plague UU was named that anyone who obstructed the inspection and investigation of a plague of the illness or in this case was the bird flu virus will be put on by the legal sanction.Sanctions that were put into effect were the punishment one prison year or the maximal Rp fine 1 million.As far as this is concerned has been seven cluster bird flu in one family in Indonesia.The case cluster most new and biggest in the world at this time was what was happen in the Karo Land.At least nine people tertular and seven including dying [read: Cluster in the Karo Land that most Big].Now the case cluster other bird flu also happened in one family in West Java.Two older brothers were siblings died resulting from cluster this bird flu.(ZIZ/Widiyaningsih and Yuyung Setiawan)</PRE>
                  http://www.liputan6.com/view/3,12350...148693656.html</PRE>

                  Comment


                  • #54
                    Re: Indonesia 5/24-5/26

                    Liputan6.com, Jakarta: the plenary Meeting of the level of the minister concerning the handling latest development of bird flu in Indonesia was spread out in Coordinating Minister for People's Welfare's Office, Jakarta the Centre, this Friday morning (26/5).This limited meeting also discussed the statement from the Health Body of the World (WHO) that revealed the existence of the spreading incident of the bird flu virus from humankind to humankind in Indonesia.Health Minister Siti Fadilah Supari, Home Minister M. Ma`ruf, and the Communications Minister and Informatika Sofyan Djalil as well as the National Commission rank Bird Flu was present in this opportunity.As for this meeting was led directly by Menkes Siti Fadilah Supari.This meeting was spread out related the discovery cluster just -- the group pengidap the bird flu virus in one family -- in the Karo Regency, North Sumatra.This case was cluster sixth and biggest in Indonesia with nine casualties who it was suspected contracted the bird flu virus.From all over the casualties seven including dying.Was based on the release that was distributed to the reporter before this meeting was spread out, it was mentioned that the status of the spreading of bird flu in Indonesia did not yet change.His status at this time still from the animal to humankind [read: Menkes: the Case of the Land Karo definitely not yet Be Antarmanusia].Resulting from the existence of the case cluster bird flu in this Karo Land forced several sides in Medan, North Sumatra, more was on the alert.The vigilance was realised with spraying disinfektan against the poultry pen and the livestock as well as giving of the vaccine to the breeders and the citizen.This step was carried out to prevent the possibility of the spreading of the bird flu virus in Medan.Was based on SCTV observation since Wednesday set, approximately 29 officials were mobilised to spray disinfektan to the livestock pen belonging to the citizen.Moreover, the owners of the livestock and the poultry were given several vaccines and disinfektan for supplies.As for the region that was given priority to to be guarded against was the Medan border with the Land karo and Deli Serdang.This region was the trade entrance in agriculture and livestock breeding headed Medan.(ZIZ/Tim Coverage 6 SCTV)</PRE>
                    </PRE>
                    http://www.liputan6.com/view/3,12348...148694148.html</PRE>

                    Comment


                    • #55
                      WHO tests show Indonesian girl died of bird flu

                      WHO tests show Indonesian girl died of bird flu
                      May 27, 2006

                      JAKARTA (Reuters) - A 10-year-old Indonesian girl who died on Tuesday in the city of Bandung was killed by the H5N1 bird flu virus, a senior health official said on Saturday, citing results from a WHO-accredited laboratory in Hong Kong.

                      "The girl is confirmed by the WHO as well as the local lab," I Nyoman Kandun, director-general of communicable disease control, told Reuters.

                      The girl's 18-year-old brother, who also died on Tuesday, tested positive locally for H5N1 this week, but was not considered a bird flu case by the Hong Kong laboratory.

                      "It's a borderline case, he tested negative for some procedures. It may be because of the procedure of specimen collection, handling, maybe the Hong Kong lab had problems. We had the same experience before in another case," Kandun said.

                      This latest confirmation of the cause of the girl's death would bring the death toll in Indonesia from bird flu to 34, and the worldwide total to 125.

                      Although the brother would not be classified as a case of H5N1 [ ], Kandun said the teenager exhibited the same clinical symptoms as his sister.

                      Dead chickens were found in the village where they lived a few days before they fell ill and the sick poultry may well have been the source of their infection, he said.

                      ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

                      Comment


                      • #56
                        Re: Indonesia BF - 5/24-5/26

                        Commentary at

                        Comment


                        • #57
                          WHO confirms three more bird flu cases in Indonesia

                          WHO confirms three more bird flu cases in Indonesia
                          27 May 2006 10:09:12 GMT
                          Source: Reuters

                          JAKARTA, May 27 (Reuters) - A shuttlecock maker and two other men in Indonesia have been infected with the H5N1 bird flu virus, a senior health official said on Saturday, citing test results from a WHO-accredited laboratory in Hong Kong.

                          The 18-year-old shuttlecock maker, who used to sort feathers in a factory in Surabaya, was alive in hospital, the official said. His condition was not immediately known.

                          The second person is a 43-year-old in Jakarta who is alive, and the third is a 39-year-old, also from the capital, but who is dead. It was not immediately clear when he died.

                          Thomson Reuters empowers professionals with cutting-edge technology solutions informed by industry-leading content and expertise.
                          ...when you have eliminated the impossible, whatever remains, however improbable, must be the truth. - Sherlock Holmes

                          Comment


                          • #58
                            Re: Indonesia BF - 5/24-5/26



                            H5N1 Bird Flu Onset Dates Confirm Human Transmission

                            Recombinomics Commentary

                            May 25, 2006

                            Fuelling the suspicion hanging over person-to-person transmission is the unusually long time lag of 15 days between the first and the last person in the cluster falling ill.

                            The incubation period for the H5N1 is usually no more than seven days and if the family had been exposed to the same source, they would all have fallen ill at about the same time.

                            "You want to look at the dates of onset of the disease. If they are close together they may have had the same exposure," Thompson said.

                            The above comments by WHO on the importance of disease onset dates in determining to source of H5N1 bird flu are also used to identify human-to-human transmission clusters. The onset dates are the most important data point because most H5N1 infections have an incubation time of 2-5 days as indicated in the New England Journal of Medicine review of H5N1 cases, authored by physicians who are WHO consultants. The 2-5 dates contradict recent comments to the New York Times that the incubation time for H5N1 was normally 7-10 days. The shorter time explains why most of the H5N1 clusters reported since 2004 have a 5-10 day gap between the index case and other family members. Half of the gap is due to the incubation time in the newly infected patients, and half is due to the time it takes for the index case to be optimally contagious.

                            Because of the importance of disease onset dates, they are usually included in WHO updates. They were withheld from descriptions of the Turkey clusters involving the two largest families, who were cousins and also withheld in the Sumatra cluster. Although onset dates were given for the first and last victim, there were no dates for the other H5N1 confirmed cases.

                            Recently, the number of suspected human-to-human clusters acknowledged by WHO has been rising. However, the vast majority of prior clusters have the 5-10 gap in disease onset dates, indicating most are due to human-to-human transmission, since bird to human infections are very rare and two independent infections from birds are unlikely. Authors from the WHO and the CDC wrote a report on the first 15 clusters, and most had the 5-10 day gap. The report was on cluster through there first cluster in Indonesia. Subsequent clusters have shown the same pattern, and clusters are common in Indonesia.

                            However, WHO investigates these cases, focusing on non-human sources and if found assuming the non-human source infected all family members, instead of just the index case. Thus, the presence of infected birds in the area does not explain the time gap, which is most easily explained by human-to-human transmission.

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