No announcement yet.

Flu shot not effective in preventing flu-related hospitalizations in asthmatic children

  • Filter
  • Time
  • Show
Clear All
new posts

  • Flu shot not effective in preventing flu-related hospitalizations in asthmatic children


    Public release date: 19-May-2009

    Contact: Keely Savoie
    American Thoracic Society
    Flu shot not effective in preventing flu-related hospitalizations in asthmatic children

    ATS 2009, SAN DIEGO? The inactivated flu vaccine does not appear to be effective in preventing influenza-related hospitalizations in children, especially the ones with asthma. In fact, children who get the flu vaccine are more at risk for hospitalization than their peers who do not get the vaccine, according to new research that will be presented on Tuesday, May 19, at the 105th International Conference of the American Thoracic Society in San Diego.

    Flu vaccine (trivalent inactivated flu vaccine?TIV) has unknown effects on asthmatics.

    "The concerns that vaccination maybe associated with asthma exacerbations have been disproved with multiple studies in the past, but the vaccine's effectiveness has not been well-established," said Avni Joshi, M.D., of the Mayo Clinic in Rochester, MN. "This study was aimed at evaluating the effectiveness of the TIV in children overall, as well as the children with asthma, to prevent influenza-related hospitalization."

    The CDC's Advisory Committee on Immunization Practices (ACIP) and the American Academy of Pediatrics (AAP) recommend annual influenza vaccination for all children aged six months to 18 years. The National Asthma Education and Prevention Program (3rd revision) also recommends annual flu vaccination of asthmatic children older than six months.

    In order to determine whether the vaccine was effective in reducing the number of hospitalizations that all children, and especially the ones with asthma, faced over eight consecutive flu seasons, the researchers conducted a cohort study of 263 children who were evaluated at the Mayo Clinic in Minnesota from six months to 18 years of age, each of whom had had laboratory-confirmed influenza between 1996 to 2006. The investigators determined who had and had not received the flu vaccine, their asthma status and who did and did not require hospitalization. Records were reviewed for each subject with influenza-related illness for flu vaccination preceding the illness and hospitalization during that illness.

    They found that children who had received the flu vaccine had three times the risk of hospitalization, as compared to children who had not received the vaccine. In asthmatic children, there was a significantly higher risk of hospitalization in subjects who received the TIV, as compared to those who did not (p= 0.006). But no other measured factors?such as insurance plans or severity of asthma?appeared to affect risk of hospitalization.

    "While these findings do raise questions about the efficacy of the vaccine, they do not in fact implicate it as a cause of hospitalizations," said Dr. Joshi. "More studies are needed to assess not only the immunogenicity, but also the efficacy of different influenza vaccines in asthmatic subjects."


  • #2
    Re: Flu shot not effective in preventing flu-related hospitalizations in asthmatic children

    I saw this , I almost posted it but figured one of you all would post it, heheh.

    I think this study helps back up my contention that vaccines are somewhat of a scam. Just because you can induce an antibody titer doesn't mean you have induced T-cell mediated immunity. The two are not one and the same! (although modern medicine seems to believe they are). Personally I think we should be focusing our time and energy on drugs such as viral RNA polymerase inhibitors rather than vaccines, especially for this flu pandemic.

    Take for example, T-705 , which is an influenza polymerase inhibitor manufactured by Toyama Pharmacuetical -- why don't we spend money on this , rather than on Baxter's sketchy vaccines? I think T-705 is in Phase 2 or Phase 3 in humans.

    See figure b

    So yeah, I think a compound like T-705 (a universal influenza polymerase inhibitor) is way more likely to save lives than a pandemic vaccine -- which may completely miss the target. The health authorities can't even make a proper seasonal flu vaccine -- what makes anyone think they can make a pandemic vaccine?

    Additionally, vaccines induce antibody production to various foreign substances, to include adjuvents and cellular material, meaning that vaccines can actually induce or worsen autoimmune disease. This is because your body recognizes most anything in the vaccine as "non-self" via MHC and responds accordingly, making antibodies to what is potentially human cellular material. Studies have now provided evidence for this effect in animals -- autoimmune damage from vaccines.

    Anyway that's my soapbox for today hahah
    Last edited by AlexanderSJones; May 19, 2009, 04:56 PM. Reason: typos