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In a new study, Yale researchers demonstrate Zika virus infection of cells derived from human placentas. The research provides insight into how Zika virus may be transmitted from expectant mother to fetus, resulting in infection of the fetal brain.
The study was published online Aug. 18 in JCI Insight.
Researchers have linked Zika virus to microcephaly?a birth defect affecting the heads and brains of infants born to infected mothers. Yet little is understood about how the virus crosses the maternal-fetal barrier, a layer of cells that serves as a filter to protect the fetus from harmful substances.
A team of researchers, led by senior author Erol Fikrig, M.D., studied the question by using three different strains of Zika virus to infect three types of cells found in placental tissue. The cells types?known as Hofbauer cells, cytotrophoblasts, and fibroblasts?were obtained from normal term pregnancies.
The researchers found that fibroblasts and Hofbauer cells were susceptible to infection by Zika virus in isolated cultures. They also observed infection of Hofbauer cells within whole placental tissue.
The study was published online Aug. 18 in JCI Insight.
Researchers have linked Zika virus to microcephaly?a birth defect affecting the heads and brains of infants born to infected mothers. Yet little is understood about how the virus crosses the maternal-fetal barrier, a layer of cells that serves as a filter to protect the fetus from harmful substances.
A team of researchers, led by senior author Erol Fikrig, M.D., studied the question by using three different strains of Zika virus to infect three types of cells found in placental tissue. The cells types?known as Hofbauer cells, cytotrophoblasts, and fibroblasts?were obtained from normal term pregnancies.
The researchers found that fibroblasts and Hofbauer cells were susceptible to infection by Zika virus in isolated cultures. They also observed infection of Hofbauer cells within whole placental tissue.
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