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High Susceptibility of Human Dendritic Cells to Avian Influenza H5N1 Virus

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    High Susceptibility of Human Dendritic Cells to Avian Influenza H5N1 Virus

    <HR style="COLOR: #cccccc" SIZE=1><!-- / icon and title --><!-- message -->
    This looks intersting.

    http://www.jimmunol.org/cgi/content/abstract/179/8/5220


    The Journal of Immunology, 2007, 179: 5220-5227.
    Copyright &#169; 2007 by The American Association of Immunologists, Inc.
    <TABLE class=content_box_outer_table align=right><TBODY><TR><TD><!-- beginning of inner table --><TABLE class=content_box_inner_table><!-- citation --><TBODY><TR><TD class=content_box_title_highlight colSpan=2>This Article</TD></TR><TR><TD class=content_box_space_between_sections colSpan=2></TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Full Text </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Full Text (PDF) </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Alert me when this article is cited </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Alert me if a correction is posted </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Citation Map </TD></TR><TR><TD class=content_box_space_between_sections colSpan=2></TD></TR><TR><TD class=content_box_title colSpan=2>Services</TD></TR><TR><TD class=content_box_space_between_sections colSpan=2></TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Similar articles in this journal </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Similar articles in PubMed </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Alert me to new issues of the journal </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Download to citation manager </TD></TR><TR><TD class=content_box_space_between_sections colSpan=2></TD></TR><TR><TD class=content_box_title colSpan=2>Google Scholar</TD></TR><TR><TD class=content_box_space_between_sections colSpan=2></TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Articles by Thitithanyanont, A. </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Articles by Pichyangkul, S. </TD></TR><TR><TD class=content_box_space_between_sections colSpan=2></TD></TR><TR><TD class=content_box_title colSpan=2>PubMed</TD></TR><TR><TD class=content_box_space_between_sections colSpan=2></TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>PubMed Citation </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Articles by Thitithanyanont, A. </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Articles by Pichyangkul, S. </TD></TR><TR><TD class=content_box_arrow vAlign=top width=4></TD><TD class=content_box_item>Pubmed/NCBI databases <TABLE class=content_box_inner_table style="FONT-SIZE: 100%" summary="Entrez Links for this Article"><TBODY style="FONT-SIZE: 100%"><TR style="FONT-SIZE: 100%"><TD style="FONT-SIZE: 100%; WHITE-SPACE: nowrap">Gene</TD><TD style="FONT-SIZE: 100%; WHITE-SPACE: nowrap">GEO Profiles</TD></TR><TR style="FONT-SIZE: 100%"><TD style="FONT-SIZE: 100%; WHITE-SPACE: nowrap">Nucleotide</TD><TD style="FONT-SIZE: 100%; WHITE-SPACE: nowrap">Protein</TD></TR><TR style="FONT-SIZE: 100%"><TD style="FONT-SIZE: 100%; WHITE-SPACE: nowrap" colSpan=2>UniGene</TD></TR><TR style="FONT-SIZE: 100%"><TD style="FONT-SIZE: 100%; WHITE-SPACE: nowrap" colSpan=2>Substance via MeSH</TD></TR></TBODY></TABLE></TD></TR></TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE>
    High Susceptibility of Human Dendritic Cells to Avian Influenza H5N1 Virus Infection and Protection by IFN- and TLR Ligands<SUP>1</SUP>

    </NOBR><NOBR>Arunee Thitithanyanont<SUP>*</SUP></NOBR>, <NOBR>Anneke Engering<SUP></SUP></NOBR>, <NOBR>Peeraya Ekchariyawat<SUP>*</SUP></NOBR>, <NOBR>Suwimon Wiboon-ut<SUP>*</SUP></NOBR>, <NOBR>Amporn Limsalakpetch<SUP></SUP></NOBR>, <NOBR>Kosol Yongvanitchit<SUP></SUP></NOBR>, <NOBR>Utaiwan Kum-Arb<SUP></SUP></NOBR>, <NOBR>Watcharoot Kanchongkittiphon<SUP>*</SUP><SUP>,</SUP></NOBR>, <NOBR>Pongsak Utaisincharoen<SUP>*</SUP></NOBR>, <NOBR>Stitaya Sirisinha<SUP>*</SUP></NOBR>, <NOBR>Pilaipan Puthavathana<SUP></SUP></NOBR>, <NOBR>Mark M. Fukuda<SUP></SUP></NOBR> and <NOBR>Sathit Pichyangkul<SUP>2</SUP><SUP>,</SUP></NOBR>

    <SUP>*</SUP> Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; <SUP></SUP> Department of Immunology and Medicine and <SUP></SUP> Department of Enteric Diseases, U.S. Army Medical Component of the Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand; and <SUP></SUP> Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    <!-- ABS -->There is worldwide concern that the avian influenza H5N1 virus,<SUP> </SUP>with a mortality rate of >50%, might cause the next influenza<SUP> </SUP>pandemic. Unlike most other influenza infections, H5N1 infection<SUP> </SUP>causes a systemic disease. The underlying mechanisms for this<SUP> </SUP>effect are still unclear. In this study, we investigate the<SUP> </SUP>interplay between avian influenza H5N1 and human dendritic cells<SUP> </SUP>(DC). We showed that H5N1 virus can infect and replicate in<SUP> </SUP>monocyte-derived and blood myeloid DC, leading to cell death.<SUP> </SUP>These results suggest that H5N1 escapes viral-specific immunity,<SUP> </SUP>and could disseminate via DC. In contrast, blood pDC were resistant<SUP> </SUP>to infection and produced high amounts of IFN-. Addition of<SUP> </SUP>this cytokine to monocyte-derived DC or pretreatment with TLR<SUP> </SUP>ligands protected against infection and the cytopathic effects<SUP> </SUP>of H5N1 virus.<SUP> </SUP>
    <!-- FN --><!-- null -->The costs of publication of this article were defrayed in part<SUP> </SUP>by the payment of page charges. This article must therefore<SUP> </SUP>be hereby marked advertisement in accordance with 18 U.S.C.<SUP> </SUP>Section 1734 solely to indicate this fact.<SUP> </SUP>
    <!-- null --><SUP>1</SUP> This work was supported by the National Center for Genetic Engineering<SUP> </SUP>and Biotechnology (BIOTEC) Thailand, the Ellison Medical Foundation<SUP> </SUP>prime grant, by Thailand Research Fund for Advanced Research<SUP> </SUP>Scholar, and by Grant Y1-AI-5026-01 from the National Institutes<SUP> </SUP>of Health, National Institute of Allergy and Infectious Diseases<SUP> </SUP>International Research in Infectious Disease.<SUP> </SUP>
    <!-- null --><SUP>2</SUP> Address correspondence and reprint requests to Dr. Sathit Pichyangkul,<SUP> </SUP>Department of Immunology and Medicine, U.S. Army Medical Component<SUP> </SUP>of the Armed Forces Research Institute of the Medical Sciences,<SUP> </SUP>315/6 Rajvithi Road, Bangkok 10400, Thailand. E-mail address:<SUP> </SUP>sathitp@afrims.org<SCRIPT type=text/javascript><!-- var u = "sathitp", d = "afrims.org"; document.getElementById("em0").innerHTML = '<a href="mailto:' + u + '@' + d + '">' + u + '@' + d + '<\/a>'//--></SCRIPT> <SUP></SUP><!-- null --><SUP>3</SUP> Abbreviations used in this paper: DC, dendritic cell; mDC, myeloid<SUP> </SUP>DC; pDC, plasmacytoid DC; MOI, multiplicity of infection.<SUP> </SUP>
    <!-- / message --><!-- sig -->
    Please do not ask me for medical advice, I am not a medical doctor.

    Avatar is a painting by Alan Pollack, titled, "Plague". I'm sure it was an accident that the plague girl happened to look almost like my twin.
    Thank you,
    Shannon Bennett
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