Viral and Inflammatory Triggers of Neurodegenerative Diseases

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Sci Transl Med 15 February 2012:
Vol. 4, Issue 121, p. 121ps3
Sci. Transl. Med. DOI: 10.1126/scitranslmed.3003492

Perspective

Neurology
Viral and Inflammatory Triggers of Neurodegenerative Diseases

Michela Deleidi1,2,? and
Ole Isacson1,2,3,4,*

+ Author Affiliations

1Harvard Medical School, Boston, MA 02115, USA.
2Neuroregeneration Laboratories at McLean Hospital, Belmont, MA 02478, USA.
3Harvard NeuroDiscovery Center, Boston, MA 02115, USA.
4Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
?Current Addresses: Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, 72076 T?bingen, Germany.

↵*Corresponding author. E-mail: Isacson@hms.harvard.edu

Abstract

Here, we synthesize research behind the emerging hypothesis that inflammation?which can result, for example, from viral infections?can initiate and propagate chronic neuronal dysfunction, an event that precedes the clinical onset of many neurodegenerative diseases. Therapeutic approaches that target immunological pathways in the prodromal phase of diseases might decrease the incidence of neurodegenerative disorders and increase the therapeutic window for neuroprotection.

Copyright ? 2012, American Association for the Advancement of Science

Citation: M. Deleidi, O. Isacson, Viral and Inflammatory Triggers of Neurodegenerative Diseases. Sci. Transl. Med. 4, 121ps3 (2012).

http://stm.sciencemag.org/content/4/121/121ps3

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Re: Viral and Inflammatory Triggers of Neurodegenerative Diseases

Influenza may increase the risk of Alzheimer

Hit us with the flu, you may think we are in the worst case may suffer from throat pain and pain to the body, but this viral infection may have lasting effects and are not visible on the brain, it may make the cells susceptible to decay and thus later Alzheimer.

The american Web site, ?Life Science? said that researchers at the University of ?Harvard? of Medicine have found that viruses such as those that cause influenza and herpes, may leave brain cells vulnerable to decay later, and increase the risk of diseases such as Alzheimer?s and Parkinson?s disease.

The researchers explained, that this comes because of the possibility of entry of virus to the brain what is happening immune reaction, or inflammation, which may expose the brain cells to be damaged.

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http://www.artcheek.com/index.php/2012/02/influenza-may-increase-the-risk-of-alzheimer/