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New swine flu has avian flu genes

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  • #31
    Re: New swine flu has avian flu genes

    Seems that the new H2N3 is a reassortant which happened in swine
    of a virus similar to A/CEID23 in PB2,PB1,NP,M,NS,
    (common ancestor 2-4 years ago) acquiring
    HA,NA,PA from an unknown bird-virus
    related to A/Mallard/Alberta/154/2003.
    The PB2 in CEID23 is of avian character and was acquired
    presumably some years before by another reassortment.
    There could have been another reassortment in PB1 but only
    mixing two similar viruses.
    It doesn't seem likely that a bird or human had caught
    a CEID23-like virus, reassorted with another virus and
    then gave that new reassorted virus back to swine. (IMO)
    The participant whose specimens yielded A/Iowa/CEID23/05 was a 50-year-old man who lived on a swine farm and was currently working with nursery and finishing swine. He self-reported having a sore throat, cough, runny/stuffed nose, and a measured oral temperature of 38.2C at the time of culture. No headache, red/itchy eyes, body aches, chills, diarrhea, nausea/vomiting, or hoarseness were reported. He also reported exposure to sick swine (with symptoms of cough, runny nose, and/or poor food intake) during the 10 days before his illness. The isolation of A/Iowa/CEID23/2005, together with the prior recovery of genotypically related reassortant influenza (H1N1) and (H3N2) viruses from 2 people following apparent zoonotic transmission from pigs (22,23), indicates that viruses of human/swine/avian triple reassortant genotype can be human pathogens.
    I'm interested in expert panflu damage estimates
    my current links: ILI-charts:


    • #32
      Re: New swine flu has avian flu genes

      paper available now:
      I'm interested in expert panflu damage estimates
      my current links: ILI-charts:


      • #33
        Re: New swine flu has avian flu genes

        I saw the link below posted on a pig site and noticed that you had mentioned the same virus in this thread, too:

        Don't know if this has any significance, but thought I'd add this here just in case.
        "As for this being a "Mexican" virus, analysis of the H sequence by BLAST [14] reveals that the closest relative to the Influenza H1N1 2009 virus previously isolated is in fact a virus 95% identical to it, from swine in Indiana in 2000 (e.g. A/Swine/Indiana/P12439/00 (H1N2)). Border interdiction makes no sense when the H gene is All-American, having been in Indiana longer than the Head Coach and most of those playing football for Notre Dame. Similarly, the closest neuramindase sequence, 94% identical, is one isolated in Britain and elsewhere in Europe in the 1990s (e.g. A/Swine/England/195852/92 (H1N1)). The parts of the virus may well have been imported into Mexico, and accidentally assembled the new influenza 2009 virus there, leading to emergence by pure happenstance."
        Genetic Characterization of H1N2 Influenza A Viruses Isolated from
        Pigs throughout the United States

        Received 30 August 2001/Returned for modification 29 November 2001/Accepted 30 December 2001
        An H1N2 influenza A virus was isolated from a pig in the United States for the first time in 1999 (A. I.
        Karasin, G. A. Anderson, and C. W. Olsen, J. Clin. Microbiol. 38:24532456, 2000). H1N2 viruses have been
        isolated subsequently from pigs in many states. Phylogenetic analyses of eight such viruses isolated from pigs
        in Indiana, Illinois, Minnesota, Ohio, Iowa, and North Carolina during 2000 to 2001 showed that these viruses
        are all of the same reassortant genotype as that of the initial H1N2 isolate from 1999.
        Never forget Excalibur.
        “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed
        Avatar: Franz Marc, Liegender Hund im Schnee 1911 (My posts are not intended as advice or professional assessments of any kind.)