Announcement

Collapse
No announcement yet.

Finland detects a new epidemic outbreak of swine flu

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Finland detects a new epidemic outbreak of swine flu

    Finland detects a new epidemic outbreak of Influenza A

    10.12.2010 / 13:40 h

    Helsinki, 10 dic (EFE) .- The Finnish health authorities have detected a new H1N1 influenza epidemic outbreak that was responsible for a pandemic in 2009, and that could be affecting hundreds of people, reported the YLE national television.

    The outbreak originated in a military barracks in the city of Parola, 110 miles north Helsinki, where about 200 recruits who perform military service show symptoms of H1N1 virus, although so far only seven cases have been confirmed.

    According to the same source, the Finnish health authorities are preparing to face a new epidemic of influenza A, as they have found several cases among the civilian population the same region and in three quarters of the west and north.

    "It is clear that the disease is spreading among the recruits, their families and other people, so it is difficult to stop an epidemic now that so many people have fallen ill, " Ilkka Julkunen told YLE, professor National Institute of Health and Welfare in Finland (THL).

    According to this expert, the next few weeks will be critical to see how quickly and virulence of the epidemic spreads, but is confident that it will not be as severe as in 2009, and More than half of the Finnish population is vaccinated.

    EFE

    (...)

    Source: http://www.abc.es/agencias/noticia.asp?noticia=620050

  • #2
    Vax Status of Soldiers at Parola (Finland)

    Do we have a report on the vaccination status of the Parola Armoured Brigade soldiers?

    Inspection of the case count against the summary number in the following categories would be worthwhile.







    Parola Armoured Brigade Vaccination Status Categories
    • trivalent 2010
    • trivalent 2010 and monovalent 2009
    • trivalent 2010 and monovalent 2009 and trivalent 2009
    The adjuvant status on each vaccine these soldiers have used would be beneficial to the discussion as well.

    While the history is being taken, perhaps the authorities could also ask about previous Influenza episode(s), duration and severity?

    Additional reports show up to 250 ill, with the hospital pressed beyond capacity so that the sick soldiers are being warehoused back to their barracks.

    The National Institute of Health and Welfare (THL) for Finland indicates that 50% of the national population has been vaccinated (in some manner), but the Vax status at the epicenter of the outbreak is not indicated in this press release?

    A certain percentage of Finnish citizens would also have develped some form of antibodies due to natural exposure (low and slow) and natural fulminant infection prior to this late Fall 2010 outbreak, raising the percentage of those deemed "protected" above the 50% that have been vaccinated in some form.

    Does this accumulation of natural antibody formation together with the vaccination "protection" not arrive at the level for required "herd immunity"? Not one of these young conscripts who are ill in their barracks at Parola appear to have benefited from "herd immunity" within their individual bodies?

    What is the probability that incompetent antibodies, of high titers and low avidity, are one of the host-pathogen interplay factors in this particular outbreak among the military, the "young and fit"?

    Additionally, you may recall that Finland recently deposited data from late November 2009 demonstrating two similar sequences displaying a very rare attempt at Immune Escape by revising the amino acid position 225 to Tyrosine, 225Y, in Finland649_2009_11_28. The related sequence, Finland648_2009_11_19, if of interest due to the predecessor date, consecutive sequence numbering and the mixed value coding for wild type AND for 225G. Data indicate that the Influenza reservoir in Finland and the surrounding geography demonstrated genetic revision throughout the pandemic.

    With that particular sequence deposit, the database of variation at the critical Receptor Binding Site position of 225 grew to double digits. Variation / Novelty in the Hemagglutinin is associated with severity of disease in Influenza and other viral presentations. PF11 (pH1N1) continues to acquire variant genetics yet today.
    Last edited by NS1; December 10, 2010, 07:06 PM. Reason: Subscribe

    Comment


    • #3
      Re: Finland detects a new epidemic outbreak of swine flu

      Last Updated 2010-12-11 The National Institute for Health and Welfare of Finland deposited a group of 133 HA sequences at GenBank on 201...


      225Y from Finland Increases Depth of Genetic Diversity
      within Critical Receptor Binding Site

      Last Updated 2010-12-11

      The National Institute for Health and Welfare of Finland deposited a group of 133 HA sequences at GenBank on 2010-11-13. The amino acid range of position 225 is extended by the mixed peaks found on an unidentified age / gender sampled on 2009-11-28, Finland649_2009_11_28. Though 225E is the most common change at the position within this geography, this particular infection attempted immune escape by revising to a Tyrosine at 225. This inflection point sample was taken at a peak of the pandemic practically one year ago and was not published until November 2010.

      . . . . Finland649_2009_11_28 (
      . . . . . . . . syn49G [MyanmarJPS020_2010_07_07
      . . . . . . . . . . . . . . . . . . . . plus 8 in 2010,
      . . . . . . . . . . . . . . India8910_2010-05-08
      . . . . . . . . . . . . . . . . . . . . with 188T,
      . . . . . . . . . . . . . . SingaporeKK081_2010_02_12,
      . . . . . . . . . . . . . . TexasJMS411_2010_01_25
      . . . . . . . . . . . . . . . . . . . . plus 2 in late 2009,
      . . . . . . . . . . . . . . Virginia01_2010_01-21,
      . . . . . . . . . . . . . . Hawaii01_2010_01-03,
      . . . . . . . . . . . . . . Hawaii02_2010_01-02,
      . . . . . . . . . . . . . . England935_2009_12,
      . . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
      . . . . . . . . . . . . . . swIowa44837_1_2009_11_08_xL
      . . . . . . . . . . . . . . . . . . . . with 225N, 230I,
      . . . . . . . . . . . . . . CaliforniaVRDL71_2009_08_28,
      . . . . . . . . . . . . . . WiscS0435_2009,
      . . . . . . . . . . . . . . HK01_2009_04_30, et al],
      . . . . . . . . syn216E,
      . . . . . . . . 225Y mix wt (kAT),
      . . . . . . . . 324I,
      . . . . . . . . syn413K)

      Another trace supporting this Finnish deposit showed a mix at 225 equating to 225G and wild type. Note the consecutive numbering of the 225Y sample to the 225G sample and the similarity of the two sequences. Of the 5 morphic positions, they share 4 and have matching revision values at 3 of those 5.

      . . . . Finland648_2009_11_19 (
      . . . . . . . . 129Q,
      . . . . . . . . syn216E,
      . . . . . . . . 225G mix wt,
      . . . . . . . . 324I,
      . . . . . . . . syn413K)

      Previously, we have detailed the genetic diversity and Vaccine Escape tendencies within this viral reservoir. 100% of the Hemagglutinin positions between 186 and 248, including antigenic areas of the Receptor Binding Domain (RBD/RBS), are on record as polymorphic. No position in that range is stable.

      Many positions rate multiple changes with position 225 increasing by the novel Tyrosine with the Finnish deposit. Protein revision is documented at 58 of the 63 positions (92%), engaging a wide potential for antibody resistance (natural Immune Escape and Vaccine Escape). Specifically, the range from 220 to 226 shows deep diversity, driving sequences that are laboratory confirmed as Low Reactors (Vaccine Escape). With the critical position 225 depth chart now moving into double digits at 10 values within this reservoir, ample consideration must be given to the rapid acquisition feature on display.

      Amino Acid Position 225 Variation in ΣPF11


      • 225D (GAt) wt
      • 225D synonymous (GAc)
      • 225A
      • 225E (GAa)
      • 225E (GAg)
      • 225E (GAa) plus 226R
      • 225G (Gga) from 225E
      • 225G (GgT)
      • 225N
      • 225V
      • 225Y

      Supporting Sequences

      . . . . Yakutsk_EAV_2009_11_18 (
      . . . . . . . . syn49G,
      . . . . . . . . syn164L [1918],
      . . . . . . . . 206S [Yaro_CHMV_2009_11_10_f (224K & 225G)],
      . . . . . . . . 286N [H3N8],
      . . . . . . . . . . . [Yaro_CHMV],
      . . . . . . . . 296H [Yaro_CHMV],
      . . . . . . . . syn348V [Yaro_CHMV,
      . . . . . . . . . . . . . . . IndiaPune10604_2009_09,
      . . . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
      . . . . . . . . . . . . . . . Eng662_2009_08],
      . . . . . . . . syn429L (TTa) [H3N8 Avian, 1918, WSN33, S5, M7],
      . . . . . . . . syn448L [S9],
      . . . . . . . . . . . . . [Yaro_CHMV],
      . . . . . . . . syn490P [S5, tn],
      . . . . . . . . . . . . . [Yaro_CHMV],
      . . . . . . . . syn511T [Yaro_CHMV],
      . . . . . . . . syn542S [H2, H5, H9N2],
      . . . . . . . . . . . . . [Yaro_CHMV])
      Last edited by NS1; December 12, 2010, 02:54 AM. Reason: content addition

      Comment

      Working...
      X