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Microbes and Infection
Volume 16, Issue 9, September 2014, Pages 755?761
Vitamin D supplementation promotes macrophages' anti-mycobacterial activity in type 2 diabetes mellitus patients with low vitamin D receptor expression
Nallely Lopez-Lopez,Irma Gonzalez-Curiel,Julio Casta?eda-Delgado,Alejandra Montoya-Rosales,Benjamin Gandara-Jasso,Jose Antonio Enciso-Moreno,Bruno Rivas-Santiago Abstract
The increasing number of people with type 2 diabetes (DM2) is alarming and if it is taken into account that the relative odds of developing tuberculosis in diabetic patients ranges from 2.44 to 8.33 compared with non-diabetic patients, thus in developing countries where these two diseases are encountering face to face, there is a need for prophylaxis strategies. The role of vitamin D has been widely implicated in growth control of Mycobacterium tuberculosis (Mtb) during primary infection mainly through the induction of certain antimicrobial peptides (AMPs). In this study we evaluated the vitamin D serum levels, CYP27B1-hydroxylase enzyme, vitamin D receptor (VDR) and AMPs gene expression in Healthy donors, DM2 and TB patients. Results showed that DM2 group has lower VDR and AMPs expression levels. When Monocytes Derived Macrophages (MDM) from DM2 patients with low VDR expression were supplemented with vitamin D, MDMs eliminate efficiently M. tuberculosis. This preliminary study suggests the use of vitamin D as prophylaxis for tuberculosis in high DM2 endemic countries.
Keywords
Volume 16, Issue 9, September 2014, Pages 755?761
Vitamin D supplementation promotes macrophages' anti-mycobacterial activity in type 2 diabetes mellitus patients with low vitamin D receptor expression
Nallely Lopez-Lopez,Irma Gonzalez-Curiel,Julio Casta?eda-Delgado,Alejandra Montoya-Rosales,Benjamin Gandara-Jasso,Jose Antonio Enciso-Moreno,Bruno Rivas-Santiago Abstract
The increasing number of people with type 2 diabetes (DM2) is alarming and if it is taken into account that the relative odds of developing tuberculosis in diabetic patients ranges from 2.44 to 8.33 compared with non-diabetic patients, thus in developing countries where these two diseases are encountering face to face, there is a need for prophylaxis strategies. The role of vitamin D has been widely implicated in growth control of Mycobacterium tuberculosis (Mtb) during primary infection mainly through the induction of certain antimicrobial peptides (AMPs). In this study we evaluated the vitamin D serum levels, CYP27B1-hydroxylase enzyme, vitamin D receptor (VDR) and AMPs gene expression in Healthy donors, DM2 and TB patients. Results showed that DM2 group has lower VDR and AMPs expression levels. When Monocytes Derived Macrophages (MDM) from DM2 patients with low VDR expression were supplemented with vitamin D, MDMs eliminate efficiently M. tuberculosis. This preliminary study suggests the use of vitamin D as prophylaxis for tuberculosis in high DM2 endemic countries.
Keywords
- Diabetes;
- Vitamin D;
- Antimicrobial peptides;
- Tuberculosis;
- Cathelicidin;
- Defensin
Vitamin D and tuberculosis: a review on a hot topic
Ludovica Facchini, Elisabetta Venturini, Luisa Galli, Maurizio de Martino, and Elena Chiappini
Journal of Chemotherapy Vol. 27 , Iss. 3,2015
Abstract
The aim of this study is to critically summarize the available data on the correlation between vitamin D level and tuberculosis (TB) infection. A literature search covering English language articles published up to 20 October 2014 was conducted in MEDLINE database. Three hundred ninety-seven articles were initially identified, of which 147 studies were initially selected, and other 13 pertinent studies were included. A significant association between low vitamin D levels and susceptibility to TB infection has been found.
Keywords: Vitamin D, Tuberculosis, Children, Hypovitaminosis D, Mycobacterium tuberculosis, Immunity
Ludovica Facchini, Elisabetta Venturini, Luisa Galli, Maurizio de Martino, and Elena Chiappini
Journal of Chemotherapy Vol. 27 , Iss. 3,2015
Abstract
The aim of this study is to critically summarize the available data on the correlation between vitamin D level and tuberculosis (TB) infection. A literature search covering English language articles published up to 20 October 2014 was conducted in MEDLINE database. Three hundred ninety-seven articles were initially identified, of which 147 studies were initially selected, and other 13 pertinent studies were included. A significant association between low vitamin D levels and susceptibility to TB infection has been found.
Keywords: Vitamin D, Tuberculosis, Children, Hypovitaminosis D, Mycobacterium tuberculosis, Immunity