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Euro Surveill. Extent and origin of resistance to antituberculosis drugs in the Netherlands, 1993 to 2011
[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]
Eurosurveillance, Volume 19, Issue 11, 20 March 2014 / Research articles
Extent and origin of resistance to antituberculosis drugs in the Netherlands, 1993 to 2011
C Ruesen <SUP>1</SUP>, A B van Gageldonk-Lafeber<SUP>1</SUP>, G de Vries<SUP>1</SUP><SUP>,2</SUP>, C G Erkens<SUP>2</SUP>, J van Rest<SUP>1</SUP><SUP>,2</SUP>, H Korthals Altes<SUP>1</SUP>, H de Neeling<SUP>3</SUP>, M Kamst<SUP>3</SUP>, D van Soolingen<SUP>3</SUP>
<SUP></SUP>
<SUP>1</SUP>Epidemiology and Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands - 2 KNCV Tuberculosis Foundation, The Hague, the Netherlands - 3 National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands
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Citation style for this article: Ruesen C, van Gageldonk-Lafeber AB, de Vries G, Erkens CG, van Rest J, Korthals Altes H, de Neeling H, Kamst M, van Soolingen D. Extent and origin of resistance to antituberculosis drugs in the Netherlands, 1993 to 2011. Euro Surveill. 2014;19(11):pii=20738. Available online: http://www.eurosurveillance.org/View...rticleId=20738
Date of submission: 28 January 2013
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The elimination of tuberculosis (TB) is threatened by an apparent increase in the level of resistance in Mycobacterium tuberculosis. In the Netherlands, where the majority of TB patients are migrants, resistance may also be increasing. We conducted a retrospective study, using 18,294 M. tuberculosis isolates from TB cases notified between 1993 and 2011. We investigated the trends in antituberculosis drug resistance, focusing on the country of birth of the patients and whether resistance had developed during treatment or was the result of transmission of resistant M. tuberculosis strains. For both scenarios, we determined whether this had happened in or outside the Netherlands. Antituberculosis drug resistance was found in 13% of all cases analysed and showed an increasing trend among patients who had been born in the Netherlands (p<0.001) and a decreasing trend among foreign-born (p=0.02) over the study period. Since 2005, the proportion of M. tuberculosis resistant strains among all strains tested has increased in both groups (p=0.03 and p=0.01, respectively). Overall, we found a significantly increasing trend when excluding streptomycin resistance (p<0.001). The trend was most markedly increased for isoniazid resistance (p=0.01). Although resistance was mainly due to transmission of resistant strains, mostly outside the Netherlands or before 1993 (when DNA fingerprinting was not systematically performed), in some cases (n=45), resistance was acquired in the Netherlands. We conclude that antituberculosis drug resistance is increasing in the Netherlands, mostly related to migration from high TB-incidence countries, but also to domestic acquisition.
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Eurosurveillance, Volume 19, Issue 11, 20 March 2014 / Research articles
Extent and origin of resistance to antituberculosis drugs in the Netherlands, 1993 to 2011
C Ruesen <SUP>1</SUP>, A B van Gageldonk-Lafeber<SUP>1</SUP>, G de Vries<SUP>1</SUP><SUP>,2</SUP>, C G Erkens<SUP>2</SUP>, J van Rest<SUP>1</SUP><SUP>,2</SUP>, H Korthals Altes<SUP>1</SUP>, H de Neeling<SUP>3</SUP>, M Kamst<SUP>3</SUP>, D van Soolingen<SUP>3</SUP>
<SUP></SUP>
<SUP>1</SUP>Epidemiology and Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands - 2 KNCV Tuberculosis Foundation, The Hague, the Netherlands - 3 National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands
______
Citation style for this article: Ruesen C, van Gageldonk-Lafeber AB, de Vries G, Erkens CG, van Rest J, Korthals Altes H, de Neeling H, Kamst M, van Soolingen D. Extent and origin of resistance to antituberculosis drugs in the Netherlands, 1993 to 2011. Euro Surveill. 2014;19(11):pii=20738. Available online: http://www.eurosurveillance.org/View...rticleId=20738
Date of submission: 28 January 2013
______
The elimination of tuberculosis (TB) is threatened by an apparent increase in the level of resistance in Mycobacterium tuberculosis. In the Netherlands, where the majority of TB patients are migrants, resistance may also be increasing. We conducted a retrospective study, using 18,294 M. tuberculosis isolates from TB cases notified between 1993 and 2011. We investigated the trends in antituberculosis drug resistance, focusing on the country of birth of the patients and whether resistance had developed during treatment or was the result of transmission of resistant M. tuberculosis strains. For both scenarios, we determined whether this had happened in or outside the Netherlands. Antituberculosis drug resistance was found in 13% of all cases analysed and showed an increasing trend among patients who had been born in the Netherlands (p<0.001) and a decreasing trend among foreign-born (p=0.02) over the study period. Since 2005, the proportion of M. tuberculosis resistant strains among all strains tested has increased in both groups (p=0.03 and p=0.01, respectively). Overall, we found a significantly increasing trend when excluding streptomycin resistance (p<0.001). The trend was most markedly increased for isoniazid resistance (p=0.01). Although resistance was mainly due to transmission of resistant strains, mostly outside the Netherlands or before 1993 (when DNA fingerprinting was not systematically performed), in some cases (n=45), resistance was acquired in the Netherlands. We conclude that antituberculosis drug resistance is increasing in the Netherlands, mostly related to migration from high TB-incidence countries, but also to domestic acquisition.
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