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Emerg Infect Dis. Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

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  • Emerg Infect Dis. Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

    [Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]


    Volume 20, Number 1—January 2014 / Dispatch

    Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

    Jean Yves Douet, Saima Zafar, Armand Perret-Liaudet, Caroline Lacroux, Séverine Lugan, Naima Aron, Herve Cassard, Claudia Ponto, Fabien Corbière, Juan Maria Torres, Inga Zerr, and Olivier Andreoletti

    Author affiliations: Ecole Nationale Vétérinaire Toulouse, France (J.Y. Douet, C. Lacroux, S. Lugan, N. Aron, H. Cassard, F. Corbière, O. Andréoletti); National Reference Center for Transmissible Spongiform Encephalopathy, Georg August University, Göttingen, Germany (S. Zafar, C. Ponto, I. Zerr); Hospices Civils de Lyon, France (A. Perret-Liaudet); BioRan, Bron, France (A. Perret-Liaudet); Centro de Investigación en Sanidad Animal, Madrid, Spain (J.M. Torres)


    Abstract

    We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to those reported in various animals with transmissible spongiform encephalopathies.


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