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J Infect Dis. The First Identification and Retrospective Study of Severe Fever with Thrombocytopenia Syndrome in Japan
[Source: The Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]
The First Identification and Retrospective Study of Severe Fever with Thrombocytopenia Syndrome in Japan
Toru Takahashi 1,*, Ken Maeda 2,*, Tadaki Suzuki 3,*, Aki Ishido 1, Toru Shigeoka 1, Takayuki Tominaga 1, Toshiaki Kamei 4, Masahiro Honda 5, Daisuke Ninomiya 6, Takenori Sakai 6, Takanori Senba 6, Shozo Kaneyuki 7, Shota Sakaguchi 8, Akira Satoh 9, Takanori Hosokawa 10, Yojiro Kawabe 11, Shintaro Kurihara 12, Koichi Izumikawa 12, Shigeru Kohno 12, Taichi Azuma 13, Koichiro Suemori 13, Masaki Yasukawa 13, Tetsuya Mizutani 14, Tsutomu Omatsu 14, Yukie Katayama 14, Masaharu Miyahara 15, Masahito Ijuin 16, Kazuko Doi 17, Masaru Okuda 18, Kazunori Umeki 19, Tomoya Saito 19, Kazuko Fukushima 19, Kensuke Nakajima 19, Tomoki Yoshikawa 20, Hideki Tani 20, Shuetsu Fukushi 20, Aiko Fukuma 20, Momoko Ogata 20, Masayuki Shimojima 20, Noriko Nakajima 3, Noriyo Nagata 3, Harutaka Katano 3, Hitomi Fukumoto 3, Yuko Sato 3, Hideki Hasegawa 3, Takuya Yamagishi 21, Kazunori Oishi 21, Ichiro Kurane 22, Shigeru Morikawa 23 and Masayuki Saijo 20,**
Author Affiliations: <SUP>1</SUP>Department of Hematology, Yamaguchi Grand Medical Center, Hofu, Yamaguchi 747-8511, Japan <SUP>2</SUP>Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan <SUP>3</SUP>Department of Pathology, National Institute of Infectious Diseases Shinjuku, Tokyo 162-8640, Japan <SUP>4</SUP>Department of Pathology, Yamaguchi Grand Medical Center, Hofu, Yamaguchi 747-8511, Japan <SUP>5</SUP>Emergency and Critical Care Medical Center, Yamaguchi Grand Medical Center, Hofu, Yamaguchi 747-8511, Japan <SUP>6</SUP>Department of Internal Medicine, Yawatahama City General Hospital, Yawatahama, Ehime 796-8502, Japan <SUP>7</SUP>Department of Internal Medicine, Dohi Hospital, Mihara, Hiroshima 723-0024, Japan <SUP>8</SUP>Department of Internal Medicine, Miyazaki Prefectural Nichinan Hospital, Nichinan, Miyazaki 887-0013, Japan <SUP>9</SUP>Section of Neurology, Nagasaki Kita Hospital, Tokitsu, Nagasaki 851-2103, Japan <SUP>10</SUP>Department of Internal Medicine, Tosa Municipal Hospital, Tosa, Kochi 781-1101, Japan <SUP>11</SUP>Department of Rheumatology, Ureshino Medical Center, Ureshino, Saga 843-0393, Japan <SUP>12</SUP>Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan <SUP>13</SUP>Department of Bioregulatory Medicine, Ehime University, Graduate School of Medicine, Toon, Ehime 791-0295, Japan <SUP>14</SUP>Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-0057, Japan <SUP>15</SUP>Department of Hematology, Karatsu Red Cross Hospital, Karatsu, Saga 847-0861, Japan <SUP>16</SUP>Community Medical Support Institute of Medicine, Saga University, Saga 840-8502 <SUP>17</SUP>Department of Dermatology, Karatsu Red Cross Hospital, Karatsu, Saga 847-0861, Japan <SUP>18</SUP>Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, 753-8515, Japan <SUP>19</SUP>Tuberculosis and Infectious Disease Control Division, Ministry of Health, Labour and Welfare of Japan, Chiyoda, Tokyo 100-8916, Japan <SUP>20</SUP>Department of Virology 1, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan <SUP>21</SUP>Infectious Disease Surveillance Center, National Institute of Infectious Diseases Shinjuku, Tokyo 162-8640, Japan <SUP>22</SUP>National Institute of Infectious Diseases Shinjuku, Tokyo 162-8640, Japan <SUP>23</SUP>Department of Veterinary Science, National Institute of Infectious Diseases Shinjuku, Tokyo 162-8640, Japan
*Corresponding author: Masayuki Saijo, MD, Ph D., Department of Virology 1, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku, Tokyo 162-8640, Japan, Tel: +81-3-4582-2660, Fax: +81-3-5285-1169, E-mail: msaijo@nih.go.jp
* Contributed equally to this work
Abstract
Background.
Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV) a novel bunyavirus reported to be endemic in central and northeastern China. This paper describes the first identification of a patient with SFTS and a retrospective study on SFTS in Japan.
Methods.
Virological and pathological examinations were performed on the patient's samples. Laboratory diagnosis of SFTS was made by isolation/genome amplification, and/or the detection of IgG antibody to SFTSV in sera. Medical doctors were alerted to the initial diagnosis and asked whether they had previously treated patients with symptoms similar to those of SFTS.
Results.
A female patient who died in 2012 was diagnosed with SFTS. Ten additional patients with SFTS were then retrospectively identified. All patients were aged 50 or over, and lived in western Japan. Six cases were fatal. The male to female ratio was 8:3. SFTSV was isolated from 8 patients. Phylogenetic analyses indicated that all the Japanese SFTSV isolates formed a genotype independent to in China. Most patients showed symptoms due to hemorrhage, possibly because of disseminated intravascular coagulation and/or hemophagocytosis.
Conclusions.
SFTS has been endemic to Japan and SFTSV has been circulating naturally within the country.
Received August 28, 2013. Revision received September 18, 2013. Accepted September 26, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com
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The First Identification and Retrospective Study of Severe Fever with Thrombocytopenia Syndrome in Japan
Toru Takahashi 1,*, Ken Maeda 2,*, Tadaki Suzuki 3,*, Aki Ishido 1, Toru Shigeoka 1, Takayuki Tominaga 1, Toshiaki Kamei 4, Masahiro Honda 5, Daisuke Ninomiya 6, Takenori Sakai 6, Takanori Senba 6, Shozo Kaneyuki 7, Shota Sakaguchi 8, Akira Satoh 9, Takanori Hosokawa 10, Yojiro Kawabe 11, Shintaro Kurihara 12, Koichi Izumikawa 12, Shigeru Kohno 12, Taichi Azuma 13, Koichiro Suemori 13, Masaki Yasukawa 13, Tetsuya Mizutani 14, Tsutomu Omatsu 14, Yukie Katayama 14, Masaharu Miyahara 15, Masahito Ijuin 16, Kazuko Doi 17, Masaru Okuda 18, Kazunori Umeki 19, Tomoya Saito 19, Kazuko Fukushima 19, Kensuke Nakajima 19, Tomoki Yoshikawa 20, Hideki Tani 20, Shuetsu Fukushi 20, Aiko Fukuma 20, Momoko Ogata 20, Masayuki Shimojima 20, Noriko Nakajima 3, Noriyo Nagata 3, Harutaka Katano 3, Hitomi Fukumoto 3, Yuko Sato 3, Hideki Hasegawa 3, Takuya Yamagishi 21, Kazunori Oishi 21, Ichiro Kurane 22, Shigeru Morikawa 23 and Masayuki Saijo 20,**
Author Affiliations: <SUP>1</SUP>Department of Hematology, Yamaguchi Grand Medical Center, Hofu, Yamaguchi 747-8511, Japan <SUP>2</SUP>Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan <SUP>3</SUP>Department of Pathology, National Institute of Infectious Diseases Shinjuku, Tokyo 162-8640, Japan <SUP>4</SUP>Department of Pathology, Yamaguchi Grand Medical Center, Hofu, Yamaguchi 747-8511, Japan <SUP>5</SUP>Emergency and Critical Care Medical Center, Yamaguchi Grand Medical Center, Hofu, Yamaguchi 747-8511, Japan <SUP>6</SUP>Department of Internal Medicine, Yawatahama City General Hospital, Yawatahama, Ehime 796-8502, Japan <SUP>7</SUP>Department of Internal Medicine, Dohi Hospital, Mihara, Hiroshima 723-0024, Japan <SUP>8</SUP>Department of Internal Medicine, Miyazaki Prefectural Nichinan Hospital, Nichinan, Miyazaki 887-0013, Japan <SUP>9</SUP>Section of Neurology, Nagasaki Kita Hospital, Tokitsu, Nagasaki 851-2103, Japan <SUP>10</SUP>Department of Internal Medicine, Tosa Municipal Hospital, Tosa, Kochi 781-1101, Japan <SUP>11</SUP>Department of Rheumatology, Ureshino Medical Center, Ureshino, Saga 843-0393, Japan <SUP>12</SUP>Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan <SUP>13</SUP>Department of Bioregulatory Medicine, Ehime University, Graduate School of Medicine, Toon, Ehime 791-0295, Japan <SUP>14</SUP>Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-0057, Japan <SUP>15</SUP>Department of Hematology, Karatsu Red Cross Hospital, Karatsu, Saga 847-0861, Japan <SUP>16</SUP>Community Medical Support Institute of Medicine, Saga University, Saga 840-8502 <SUP>17</SUP>Department of Dermatology, Karatsu Red Cross Hospital, Karatsu, Saga 847-0861, Japan <SUP>18</SUP>Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, 753-8515, Japan <SUP>19</SUP>Tuberculosis and Infectious Disease Control Division, Ministry of Health, Labour and Welfare of Japan, Chiyoda, Tokyo 100-8916, Japan <SUP>20</SUP>Department of Virology 1, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan <SUP>21</SUP>Infectious Disease Surveillance Center, National Institute of Infectious Diseases Shinjuku, Tokyo 162-8640, Japan <SUP>22</SUP>National Institute of Infectious Diseases Shinjuku, Tokyo 162-8640, Japan <SUP>23</SUP>Department of Veterinary Science, National Institute of Infectious Diseases Shinjuku, Tokyo 162-8640, Japan
*Corresponding author: Masayuki Saijo, MD, Ph D., Department of Virology 1, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku, Tokyo 162-8640, Japan, Tel: +81-3-4582-2660, Fax: +81-3-5285-1169, E-mail: msaijo@nih.go.jp
* Contributed equally to this work
Abstract
Background.
Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV) a novel bunyavirus reported to be endemic in central and northeastern China. This paper describes the first identification of a patient with SFTS and a retrospective study on SFTS in Japan.
Methods.
Virological and pathological examinations were performed on the patient's samples. Laboratory diagnosis of SFTS was made by isolation/genome amplification, and/or the detection of IgG antibody to SFTSV in sera. Medical doctors were alerted to the initial diagnosis and asked whether they had previously treated patients with symptoms similar to those of SFTS.
Results.
A female patient who died in 2012 was diagnosed with SFTS. Ten additional patients with SFTS were then retrospectively identified. All patients were aged 50 or over, and lived in western Japan. Six cases were fatal. The male to female ratio was 8:3. SFTSV was isolated from 8 patients. Phylogenetic analyses indicated that all the Japanese SFTSV isolates formed a genotype independent to in China. Most patients showed symptoms due to hemorrhage, possibly because of disseminated intravascular coagulation and/or hemophagocytosis.
Conclusions.
SFTS has been endemic to Japan and SFTSV has been circulating naturally within the country.
Received August 28, 2013. Revision received September 18, 2013. Accepted September 26, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com
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