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http://aje.oxfordjournals.org/content/154/2/106.full
Am. J. Epidemiol. (2001) 154 (2): 106-114. doi: 10.1093/aje/154.2.106
Parental Occupational Exposures to Chemicals and Incidence of Neuroblastoma in Offspring
Anneclaire J. De Roos 1 , 6 ,
Andrew F. Olshan 1 ,
Kay Teschke 2 ,
Charles Poole 1 ,
David A. Savitz 1 ,
Julie Blatt 3 ,
Melissa L. Bondy 4 and
Brad H. Pollock 5
+ Author Affiliations
1Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC.
2Department of Health Care Epidemiology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
3Division of Pediatric Hematology/Oncology, School of Medicine, University of North Carolina, Chapel Hill, NC.
4Department of Epidemiology, M. D. Anderson Cancer Center, University of Texas, Houston, TX.
5Department of Health Policy and Epidemiology, School of Medicine, University of Florida, Gainesville, FL.
6Current address: Occupational Epidemiology Branch, National Cancer Institute, Bethesda, MD.
Received September 8, 2000.
Accepted January 31, 2001.
Abstract
To evaluate the effects of parental occupational chemical exposures on incidence of neuroblastoma in offspring, the authors conducted a multicenter case-control study, using detailed exposure information that allowed examination of specific chemicals. Cases were 538 children aged 19 years who were newly diagnosed with confirmed neuroblastoma in 1992?1994 and were registered at any of 139 participating hospitals in the United States and Canada. One age-matched control for each of 504 cases was selected through random digit dialing. Self-reported exposures were reviewed by an industrial hygienist, and improbable exposures were reclassified. Effect estimates were calculated using unconditional logistic regression, adjusting for child's age and maternal demographic factors. Maternal exposures to most chemicals were not associated with neuroblastoma. Paternal exposures to hydrocarbons such as diesel fuel (odds ratio (OR) = 1.5; 95% confidence interval (CI): 0.8, 2.6), lacquer thinner (OR = 3.5; 95% CI: 1.6, 7.8), and turpentine (OR = 10.4; 95% CI: 2.4, 44.8) were associated with an increased incidence of neuroblastoma, as were exposures to wood dust (OR = 1.5; 95% CI: 0.8, 2.8) and solders (OR = 2.6; 95% CI: 0.9, 7.1). The detailed exposure information available in this study has provided additional clues about the role of parental occupation as a risk factor for neuroblastoma.
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Am. J. Epidemiol. (2001) 154 (2): 106-114. doi: 10.1093/aje/154.2.106
Parental Occupational Exposures to Chemicals and Incidence of Neuroblastoma in Offspring
Anneclaire J. De Roos 1 , 6 ,
Andrew F. Olshan 1 ,
Kay Teschke 2 ,
Charles Poole 1 ,
David A. Savitz 1 ,
Julie Blatt 3 ,
Melissa L. Bondy 4 and
Brad H. Pollock 5
+ Author Affiliations
1Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC.
2Department of Health Care Epidemiology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
3Division of Pediatric Hematology/Oncology, School of Medicine, University of North Carolina, Chapel Hill, NC.
4Department of Epidemiology, M. D. Anderson Cancer Center, University of Texas, Houston, TX.
5Department of Health Policy and Epidemiology, School of Medicine, University of Florida, Gainesville, FL.
6Current address: Occupational Epidemiology Branch, National Cancer Institute, Bethesda, MD.
Received September 8, 2000.
Accepted January 31, 2001.
Abstract
To evaluate the effects of parental occupational chemical exposures on incidence of neuroblastoma in offspring, the authors conducted a multicenter case-control study, using detailed exposure information that allowed examination of specific chemicals. Cases were 538 children aged 19 years who were newly diagnosed with confirmed neuroblastoma in 1992?1994 and were registered at any of 139 participating hospitals in the United States and Canada. One age-matched control for each of 504 cases was selected through random digit dialing. Self-reported exposures were reviewed by an industrial hygienist, and improbable exposures were reclassified. Effect estimates were calculated using unconditional logistic regression, adjusting for child's age and maternal demographic factors. Maternal exposures to most chemicals were not associated with neuroblastoma. Paternal exposures to hydrocarbons such as diesel fuel (odds ratio (OR) = 1.5; 95% confidence interval (CI): 0.8, 2.6), lacquer thinner (OR = 3.5; 95% CI: 1.6, 7.8), and turpentine (OR = 10.4; 95% CI: 2.4, 44.8) were associated with an increased incidence of neuroblastoma, as were exposures to wood dust (OR = 1.5; 95% CI: 0.8, 2.8) and solders (OR = 2.6; 95% CI: 0.9, 7.1). The detailed exposure information available in this study has provided additional clues about the role of parental occupation as a risk factor for neuroblastoma.