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Pesticide linked to three generations of disease (adult onset kidney disease, ovarian disease and obesity)

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  • Pesticide linked to three generations of disease (adult onset kidney disease, ovarian disease and obesity)
    Pesticide linked to three generations of disease
    July 24, 2014
    By Becky Phillips, University Communications

    PULLMAN, Wash. ? Washington State University researchers say ancestral exposures to the pesticide methoxychlor may lead to adult onset kidney disease, ovarian disease and obesity in future generations.

    ?What your great-grandmother was exposed to during pregnancy, like the pesticide methoxychlor, may promote a dramatic increase in your susceptibility to develop disease, and you will pass this on to your grandchildren in the absence of any continued exposures,? says Michael Skinner, WSU professor and founder of its Center for Reproductive Biology.

    He and his colleagues document their findings in a paper published online in PLOS ONE ( The study was funded by the National Institutes of Health.
    DDT replacement banned in 2003

    Methoxychlor?also known as Chemform, Methoxo, Metox or Moxie?was introduced in 1948 and widely used during the 1970s as a safer replacement for DDT. It was used on crops, ornamental plants, livestock and pets. It is still used in many countries around the world.


    Implications for obesity, fertility, disease

    The work is the first to show that a majority of transgenerational disease traits can be transmitted primarily through the female line.

    Additionally, the study identified mutations in the sperm epigenome of great-grandchild male rats. The epigenome functions like a set of switches for regulating gene expression and can be altered by environmental conditions.

    The epigenetic changes observed were specific to methoxychlor exposure and may prove to be valuable biomarkers for future research on transgenerational disease.

    For people exposed to the pesticide, Skinner says his findings have implications such as reduced fertility, increased adult onset disease and the potential to pass on those conditions to subsequent generations.

    He suggests that ancestral exposures to methoxychlor over the past 50 years in North America may play a part in today?s increasing rates of obesity and disease.
    Michael Skinner, WSU School of Biological Sciences [See link for contact info]

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