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H7N9, Taiwan: Avian influenza virus isolated from first patient possibly partially resistant to oseltamivir (Ifeng, May 17 2013)

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  • H7N9, Taiwan: Avian influenza virus isolated from first patient possibly partially resistant to oseltamivir (Ifeng, May 17 2013)

    [Source: Ifeng, full text: (LINK). Automatic translation from Chinese.]
    H7N9, Taiwan: Avian influenza virus isolated from first patient possibly partially resistant to oseltamivir

    2013 05 17, 2007 17:15 Source: China Taiwan network


    China Taiwan Network May 17, according to Taiwan's "Central News Agency" reports, Taiwan's first case of H7N9 infection has transferred to the general ward, National Taiwan University Hospital inspection found that infected individuals with the deposit resistant and non-resistant strain of the virus, treatment difficult, but fortunately the ability of the virus of human-to-human transmission is limited.

    National Taiwan University Hospital, director of the Pediatric Infectious Diseases, Li-Min Huang explained that the H7N9 virus may invade the body does not have the resistance to the invasion natural evolution of H7N9 Tamiflu resistant, co-existence and non-drug-resistant strains of the virus, due to the patient's condition is serious, National Taiwan University The hospital medical team for another antiviral injections.

    Li-Min Huang said, The sick Taiwanese with both viruses at the same time makes the medical staff not easy to judge whether the ineffective treatment for drug resistance.

    H7N9 Tamiflu resistant is not common, other viral drugs still effective, and H7N9 caused lung disease, but not infection of the upper respiratory tract, the patient does not appear runny nose, sneezing and other symptoms, so the virus will not be from the nose The pharyngeal opening secretion droplets.

    Sick Taiwanese go from March 28 to April 9, Suzhou City, Jiangsu Province , returned to Taiwan via Shanghai on April 9, the onset of the 12th. 20 turn into National Taiwan University Hospital, ECMO about 9-10 days to maintain heart and lung function, has dropped before ECMO, endotracheal intubation, turn into the general ward from the intensive care unit.

    (China Taiwan Network Shuai)
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  • #2
    Re: H7N9, Taiwan: Avian influenza virus isolated from first patient possibly partially resistant to oseltamivir (Ifeng, May 17 2013)

    H7N9 case has drug- and non-resistant strains

    The China Post news staff

    May 18, 2013, 12:00 am TWN

    TAIPEI, Taiwan -- The only H7N9 patient so far in Taiwan was carrying two strains of the same virus, with one being drug resistant and the other not, making it tricky to treat to him, doctors said yesterday.

    Huang Li-min, a doctor from National Taiwan University Hospital (NTUH), explained that it was possible the avian flu virus was not drug resistant when the patient was first infected, but mutated later to become resistant to Tamiflu.

    With Tamiflu failing, NTUH later switched to another intravenous drug, Huang said. Because of the presence of the two strains simultaneously, it was difficult for doctors to determine how much the virus' drug resistance had undermined the therapy.

    Chou Chi-hao, deputy director-general of the Centers for Disease Control (CDC), said it is natural for viruses to mutate, saying the H1N1 flu strain mutated after infecting human beings.

    But Huang said H7N9 has limited chances of human-to-human transmission through respiratory secretions because the virus has difficulty surviving the environments of human upper respiratory systems. Patients do not have symptoms of a runny nose or sneezing.

    The patient, surnamed Lee, got sick on April 12, three days after returning from a business trip in China. His condition was initially critical, but has improved much. He has already been transferred from the intensive care unit to an ordinary ward at NTUH.

    The findings by the NTUH and CDC about H7N9 are to be published in a local medical journal next month.

    China Post
    "Addressing chronic disease is an issue of human rights that must be our call to arms"
    Richard Horton, Editor-in-Chief The Lancet

    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

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    • #3
      Re: H7N9, Taiwan: Avian influenza virus isolated from first patient possibly partially resistant to oseltamivir (Ifeng, May 17 2013)

      A preliminary clinical description and treatment protocol was published earlier at:

      Source: The Lancet, full text: http://download.thelancet.com/flatcontentassets/pdfs/S0140673613609435.pdf

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