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Singapore Breakthrough in Fight Against Chikungunya

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  • Singapore Breakthrough in Fight Against Chikungunya

    Source: http://www.thejakartaglobe.com/home/...ungunya/422952

    Singapore Breakthrough in Fight Against Chikungunya
    Judith Tan - Straits Times Indonesia | February 16, 2011

    Breakthrough in fight against chikungunya
    S'pore team discovers 2 antibodies that could neutralise virus strains

    By Judith Tan

    Singapore. Scientists in Singapore have moved a step closer to developing a treatment for chikungunya, a disease spread by the Aedes mosquito.

    They have discovered two monoclonal antibodies - meaning they were developed from single cells - which could neutralise several chikungunya strains in a laboratory setting...

  • #2
    Re: Singapore Breakthrough in Fight Against Chikungunya

    Source: http://www.theborneopost.com/2012/03...ter-treatment/


    Breakthroughs in Chikungunya research spell new hope for better treatment
    Posted on March 15, 2012, Thursday

    SINGAPORE: Recent breakthroughs in Chikungunya research spearheaded by scientists at A*STARís Singapore Immunology Network (SIgN) have made great strides in the battle against the infectious disease.

    Working in close collaborations with Singapore clinician-scientists and international researchers, Dr Lisa Ng, Principal Investigator of the Chikungunya research group at SIgN, led the team to discover a direct biomarker which serves as an early and accurate prognosis of patients who have a higher risk of the more severe form of Chikungunya fever (CHIKF).

    This means that doctors can now quickly and accurately identify patients at risk, facilitating a more targetted treatment and clinical care at the onset of the disease...

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    • #3
      Re: Singapore Breakthrough in Fight Against Chikungunya

      Source: http://www.asianscientist.com/health...ya-fever-2012/

      Scientists Discover Biomarker For Severe Form Of Chikungunya Fever
      Scientists Discover Biomarker For Severe Form Of Chikungunya Fever

      By Rebecca Lim | Health & Medicine
      March 16, 2012

      A biomarker that identifies patients at risk of the more severe form of Chikungunya fever has been discovered by scientists at A*STARís Singapore Immunology Network.

      AsianScientist (Mar. 16, 2012) Ė A biomarker that identifies patients at risk of the more severe form of Chikungunya fever (CHIKF) has been discovered by scientists at A*STARís Singapore Immunology Network (SIgN).

      This breakthrough, made by Dr. Lisa Ng and her local and international colleagues, showed that patients who respond to the disease at the onset with high levels of immunoglobulin G3 (IgG3), a naturally-acquired antibody, are protected from the more severe form of Chikungunya fever, which is characterized by persistent joint pains.

      On the other hand, patients with a delayed IgG3 response generally have less acute symptoms at the start, but are more susceptible to chronic debilitating joint pains at later stages of the disease.

      Hence, the delayed appearance of IgG3 antibodies serves as a specific biomarker for patients with an increased risk of the severe form of the disease...

      ...The article can be found at: Kam YW et al. (2012) Early Appearance of Neutralizing Immunoglobulin G3 Antibodies Is Associated With Chikungunya Virus Clearance and Long-term Clinical Protection.

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