Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

[Giuseppe]

Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

A genetic mutation of the new strain of influenza A virus resistant to Tamiflu has been detected in a woman who has not been given the anti-flu drug, health authorities said Wednesday. The health ministry said the incident could mark the first case of a human-to-human infection of the H1NI flu virus.
==Kyodo


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[sharon sanders]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

Tamiflu Metabolite Measured In Japanese Sewage Discharge, River Water

http://www.flutrackers.com/forum/showthread.php?t=126849

[Commonground]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

[New] flu-infected person who discovered the possibility of Tamiflu-resistant

2009.10.8 00:52

Ministry of Health yesterday, the new flu on August 22 in Sapporo to seek medical attention from a 10-something women, announced that the virus has been detected with full Tami antiviral drug resistance. Women are treated with Relenza, Tamiflu is not taken.

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[Commonground]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

New Tamiflu-resistant flu, Sapporo or first person infected

2009年10月7日23時12分

October 7, 2009 23:12


Ministry of Health and Sapporo on June 7 from patients infected with swine flu in the new city, announced the discovery of resistant virus could be resistant to the antiviral drug Tamiflu.

新型インフルのタミフル耐性例は国内８例目だが、今回の患者自身はタミフルを使っておらず、初めて人から感 染した事例の可能性もある。

Tamiflu-resistant flu cases in the new country, but of eight cases, the patient's own Tamiflu does not use this, possibly the first cases of infected people.

これまでの例は、タミフルを服用するうちに患者の体内で変異して耐性を持ったと見られていた。

Previous cases had been seen as the resistant mutant in the body of the patient taking Tamiflu.

厚労省などによると、患者は１０代女性。

According to the ministry, the patient is 10 year-old women.

８月２２日、発熱して受診した札幌市内の医療機関で簡易検査が陽性で別の抗ウイルス薬のリレンザを投与、翌 日には熱が下がった。

August 22, administered the antiviral drug Relenza is another simple test positive at the Sapporo Medical examination in the heat, the heat went down the next day.

９月下旬になって、同市衛生研究所の遺伝子検査でタミフル耐性の結果が出た。

Is in late September, showed Tamiflu-resistant genetic testing laboratory in the city's health.

このため、改めて国立感染症研究所で調査、今月６日に耐性だと確定した。

Therefore, the National Research Institute of Infectious Diseases in again, this month confirmed it resistant to six days.

女性の家族は発症しておらず、周辺でタミフルを服用して症状が改善しない患者は増えていない。

Family of women has not developed symptoms, the symptoms do not improve patient taking Tamiflu has not increased around.

これまでの報告例では、耐性ウイルスは感染力が弱かった。

The cases reported so far, the weak force resistant virus infection.

今回、人から感染していた場合、感染力を持った可能性もあるが、厚労省は、感染拡大は起きていないとしてい る。

This time, when people were infected, could be infected with the power ministry, the spread has not happened.

同省は、「人から感染したのか、ウイルスが体内で変異したのかわからない」としている。

Ministry, "or from an infected person does not know how the virus mutated in the body" and that.

（野瀬輝彦、小林舞子）

(Nose Teruhiko, Maiko Kobayashi)

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[Commonground]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

10 year-old women in Sapporo, Tamiflu-resistant "new"





Ministry of Health and Sapporo on June 7 in the city of Sapporo pandemic influenza-infected 10-something woman, announced that it has detected a virus resistant to treatment Tami track. <!--// rectangle_start //--><script type="text/javascript"> AD2.init({site:'NATIONAL', area:'P.RECTANGLE', width:300, height:250, admax:1}); </script><script src="http://as.yl.impact-ad.jp/bservers/AAMALL/acc_random=14570071/pageid=98353563/AAMB0/SITE=NATIONAL/AREA=P.RECTANGLE/AAMSZ=300X250/OENCJP=SJIS"></script><script type="text/javascript"> AD2.cAds(); </script><script type="text/javascript">AD2.dBanner(0,'prect');</script><style type="text/css">#rect-l{position:relative;left:-5px}</style>
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耐性ウイルスは国内では８例目の検出だが、タミフルを服用していない患者からの検出は国内では 初めて。

Resistant virus was first detected in eight cases, but detection of patients taking Tamiflu is not the first time in the country.

人から人に感染する耐性ウイルスの可能性もある。

Resistant virus could be transmitted from person to person.

女性は８月に発症し、治療薬リレンザを投与され回復。

She developed symptoms on 8 Mon, recovering drug Relenza is administered.

今月６日に国立感染症研究所の調査でタミフル耐性ウイルスと判明した。

Tamiflu-resistant virus was found earlier this month by the National Research Institute of Infectious Diseases days.

厚労省は「今後、周辺に感染の広がりがあるか注視する必要がある」としている。

The ministry is "the future, if there is a need to gaze around the spread of infection" and that.

（

( <!--// date_start //-->

2009年10月8日01時22分

October 8, 2009 at 22 minutes 01 <!--// date_end //-->

読売新聞）

The Yomiuri Shimbun)

[Commonground]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

Tamiflu-resistant virus, or infection of the first = 10 year-old women - the new flu Sapporo



Ministry of Health and Sapporo on June 7, 10, had announced that a new influenza virus that are resistant to anti-influenza drug Tamiflu to teenage women.

同省によると、女性はタミフルを投与されておらず、ほかの患者から耐性ウイルスをうつされた可能性があるが 、感染ルートは不明。

According to the ministry, women are not treated with Tamiflu, but there is a possibility that the resistant virus from patients Utsusa other route of infection is unknown.

同省によると、国内ではこれまでに７人から耐性ウイルスが検出されているが、いずれもタミフルを服用してお り、本人の体内で変異した可能性が高いとみられている。

According to the ministry, the country is so far the seven-resistant virus has been detected from the people taking Tamiflu, and both are believed likely that mutations in the body of the person.

女性は８月２０日にせきの症状が表れ、同２２日に発熱。

Women on August 20 a day manifestation of symptoms of cough, fever in the same 22 days.

リレンザを投与され、熱が下がった。

Relenza is administered, the fever dropped.

同市衛生研究所はウイルスの遺伝子検査をし、９月２５日に耐性が分かった。

Institute of Health genetic testing of the virus to the city on September 25 showed resistance to the Sun.

（2009/10/08-00:18）

(2009/10/08-00: 18)

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[Commonground]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

Sapporo's new flu-infected patients or people with resistant virus

2009/10/08 01:29

Ministry of Health and Sapporo on June 7, and seek medical attention for the city's 10 new flu virus was detected in patients with the woman announced that a gene mutation was found resistant to Tamiflu treatment.

厚労省によると、タミフル耐性ウイルスの確認は国内８例目だが、今回の患者はタミフルを使用しておらず、初 めてほかの人から感染した可能性があるという。

According to the ministry, confirmed Tamiflu-resistant virus, but eight of the domestic cases, this patient was not using Tamiflu, that there is a possibility of infection from other people first.

タミフル耐性が確認されたこれまでの例では、服用した患者の体内でウイルスが変異し、耐性を持ったとみられ ていた。

This was confirmed in cases of resistance to Tamiflu, the virus mutated in patients taking the body, with a resistance was expected.

厚労省などによると、女性は８月２２日に発熱し、医療機関で別の治療薬リレンザを投与されて翌日に解熱した 。

According to the ministry, the woman developed fever on August 22 and Sun, the day after antipyretic drug Relenza is administered by medical institutions.

９月２５日になって札幌市衛生研究所での遺伝子検査でタミフルへの耐性が判明。

September 25 found that genetic testing of resistance to Tamiflu in Sapporo City Institute of Public Health is in the Sun.

今月６日に国立感染症研究所で確定した。

This month the final six days at the National Institute of Infectious Diseases.

札幌市は女性の家族や周辺地域でタミフルの服用後に症状が改善しなかったりしたケースは確認していないとし ている。

Sapporo is the case or does not improve after taking Tamiflu symptoms in women family and the surrounding area has not been confirmed.

厚労省は「タミフル耐性を持つウイルスの女性からの感染拡大は確認されていない。女性が人から感染した可能 性は否定できない」としている。

The ministry is "the spread of Tamiflu-resistant virus from women has not been confirmed. The possibility of infection from a woman who can not be denied" and that.

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[Commonground]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

Drug-resistant flu can spread

Oct 8, 2009

TOKYO - A GENETIC mutation of H1N1 swine flu that is resistant to the antiviral drug Tamiflu has been detected in a Japanese teenager who had not previously been treated with the drug, a Japanese health official said.
The case could mark Japan's first instance of person-to-person transmission of a Tamiflu-resistant strain of the H1N1 flu but Health Ministry official Takeshi Enami said there was still insufficient evidence to confirm that.



'We cannot deny that this could be person-to-person transmission, but we are not able to reach that conclusion,' Mr Enami said. Japan has had eight cases of new H1N1 patients who were resistant to Tamiflu, he added.
The mutation was detected by health officials in Sapporo, northern Japan, in a teenage girl who had developed a fever on Aug 22. She was given GlaxoSmithkline's Relenza and recovered a day later, the ministry said in a statement.



The detected mutation did not worsen the virus, nor were there signs of an unusual rise in new H1N1 cases nearby, it said.
The risk of resistance is higher in patients who suffer from weak immune systems and have already been treated with Tamiflu, manufactured by Roche Holding under license from Gilead Sciences. -- REUTERS

http://www.straitstimes.com/Breaking%2BNews/Asia/Story/STIStory_439616.html

[Commonground]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

Interesting that a sequence was deposited from Sapporo already.


LOCUS GQ365448 1410 bp cRNA linear VRL 21-JUL-2009
DEFINITION Influenza A virus (A/Sapporo/1/2009(H1N1)) segment 6 neuraminidase
(NA) gene, complete cds.
ACCESSION GQ365448
VERSION GQ365448.1 GI:251833647
DBLINK Project:37813
KEYWORDS .
SOURCE Influenza A virus (A/Sapporo/1/2009(H1N1))
ORGANISM Influenza A virus (A/Sapporo/1/2009(H1N1))
Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
Influenzavirus A.
REFERENCE 1 (bases 1 to 1410)
AUTHORS Ujike,M., Obuchi,M., Tashiro,M., Horikawa,H., Kato,Y., Oguchi,A.,
Fujita,N. and Odagiri,T.
TITLE Human infection with novel swine H1N1 influenza
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1410)
AUTHORS Horikawa,H., Kato,Y., Oguchi,A. and Fujita,N.
TITLE Direct Submission
JOURNAL Submitted (08-JUL-2009) National Institute of Technology and
Evaluation (NITE), Tokyo, Japan
REFERENCE 3 (bases 1 to 1410)
AUTHORS Ujike,M., Obuchi,M., Tashiro,M. and Odagiri,T.
TITLE Direct Submission
JOURNAL Submitted (08-JUL-2009) National Institute of Infectious Diseases,
4-7-1, Gakuen, Musashi-murayama, Tokyo 208-0011, Japan
COMMENT GenBank Accession Numbers GQ365446-GQ365453 represent sequences
from the 8 segments of Influenza A virus (A/Sapporo/1/2009(H1N1)).

Swine influenza A (H1N1) virus isolated during human swine flu
outbreak of 2009.

-snip-

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=nucleotide&dopt=GenBank&RID=5EV5Y2P101R&log%24=nucltop&blast_rank=2&list_uids=251833647

</pre>

[Commonground]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

Japan Tamiflu-resistant H1N1 teen had no Tamiflu record


Thu Oct 8, 2009 8:41am IST
TOKYO (Reuters) - A genetic mutation of H1N1 swine flu that is resistant to the antiviral drug Tamiflu has been detected in a Japanese teenager who had not previously been treated with the drug, a Japanese health official said.

The case could mark Japan's first instance of person-to-person transmission of a Tamiflu-resistant strain of the H1N1 flu but Health Ministry official Takeshi Enami said there was still insufficient evidence to confirm that.

"We cannot deny that this could be person-to-person transmission, but we are not able to reach that conclusion," Enami said. Japan has had eight cases of new H1N1 patients who were resistant to Tamiflu, he added.

The Geneva-based World Health Organisation (WHO) said in late September that drug-resistant pandemic flu viruses had appeared infrequently and there was no evidence that they were spreading, but that further cases were likely.

The mutation was detected by health officials in Sapporo, northern Japan, in a teenage girl who had developed a fever on Aug. 22. She was given GlaxoSmithkline's Relenza and recovered a day later, the ministry said in a statement.

The detected mutation did not worsen the virus, nor were there signs of an unusual rise in new H1N1 cases nearby, it said.

The risk of resistance is higher in patients who suffer from weak immune systems and have already been treated with Tamiflu, manufactured by Roche Holding under license from Gilead Sciences.

It is also high in people who are treated with antivirals as a precaution after exposure to someone with influenza but nevertheless develop the disease.

(Reporting by Linda Sieg and Yoko Nishikawa; Editing by Rodney Joyce and Edwina Gibbs)

http://in.reuters.com/article/worldNews/idINIndia-42994820091008

[Mamabird]

Re: Japan. Tamiflu-resistant new influenza detected in patient not given Tamiflu

Interesting that a sequence was deposited from Sapporo already.

Older isolate collected back in June. Not Tamiflu resistant.